Hmdb loader

Showing Protein F-box only protein 43 (HMDBP07682)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP07682
Secondary Accession Numbers
  • 13391
Name F-box only protein 43
Synonyms
  1. Endogenous meiotic inhibitor 2
Gene Name FBXO43
Protein Type Unknown
Biological Properties
General Function Involved in zinc ion binding
Specific Function Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable)
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
transition metal ion binding
zinc ion binding
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:8
Locus 8q22.2
SNPs FBXO43
Gene Sequence 
>2127 bp
ATGAGTTTTAAAGACAAAGATGAGAGAATTTCTTGTTTGGAAGCCTACGTAACTTTGACA
TCTAAGAGCTCAAGATTTACTGATGAAACAGAGATTTTGAAGATGTCGCAAAGGCACTCA
GGTCAAGCTGGCACTGAAGCAGGAAATGGGGCGGACTCTCCTCCAATTGTCAACTCCAAG
TACTCCACCTTCAGAGATTTTTGTTCCACATCTTCATTTCAAGATAGTGGCTACAATGAG
TTAAAATCTTGTAGCTTTGATAATATAGATAAAGAATATCTTGGAAAGAAAGAAAAAGGC
CCAACATTACTCTATGAGCACCCTGAAACTTCAGGCCTGGGCTTAACACATCCTTTAGAA
TCTCCCACTCAAAAAAAGAAATGTATCTTGCCTAGAAAGGAAAAGGATAAAACCCCAGAA
CTTTGTGAAACACCTAAAATCAGTGGGAAAAAATGTTTACCTCGCAGAAGGTTGAATGTA
TCTTTCGCTCTTCTAAAAGGGGACTTTGAATCACAAAATAGTTCTTTAGAAAGTAGTATA
AGCCAAGTTATCAACTTAGAAAAAAATATTCCAAGCAGTGCTTCAGGTTTTTCCAGGGCA
AATAATTTTAGCCCTTTAGTTACTAGCACTTTAAAAACAGAAGAAGTGACTTCATGCAGT
CAAAAATTGAGGCTTAATTTTTCTCAGCAAAAGACTTCCACAATTGATGATTCCAAAGAT
GATTGTAGCCTATTTGAAGTTGAATGTATATCTCCAATTCAGGGCAATAATTTTAAAGAC
TCTATCACACATGACTTTAGTGATAGCAGTTTATGCATTAATGATGAGAATGCATGTCCA
GAGCTCCTGGGCTCCTCTGTTAGTGGAACAACTTGTGGAACAGATGAGGACATATTTGTG
ACTCCGATAAGTAATCTTGTGGCAAACATTAGATTTAACGCAAGTCAAATACTTTCTCCT
TCACCTGAAGTGAGAGGCAGTATTTCAACGCCTGAAGACAGTGGTTTTAACTCACTTAGC
TTGGAGAAATCAGAAGATTCCCTGTCTGACCAGGAGGGTTCTTTTCAAGAACTACTGCAG
AAACATAAGGGGACTCCCAAAGTTGGGGACACCATAAGAAAGACAAGACATCTTGGAAGG
TCGAGAAGACTGTCCACCCTTCGGGAACAAAGCTCGCAGTCAGAGACAGAAGAGGAAAAG
CAGATTGTCCACCCTGACTCTGAAAAAAGAGCAGCAGCTGCTTCTGCCATCTCAGAGGGT
CAGCTGAGTAGTGATGAGAGTGGGGATTTGACCTTTAGCTTAAAGAATTTATCAAAGACC
CCAGCCTTGCAATTGGTACATGAGCTGTTCATGAAAAGCAAGAGGAAAAGATTACAGGAA
AATAGTGGACATGAATTCTTAGAGCAAGGGGATGGGGAGAAAATAGCTGTACTGCAGTGT
ATACTTGCAGGACTGATCGGCAAGAAAATGGGTATAGAAAAACTGGACATCTTAACAGAA
TTAAAATATAGAAATTTAAAGCATATTCTTGCTATGGTTTTAGAGTCCTTGACCGCAGAG
AGCCTATGCAGTGTTTGGAAAGTAAGCAGAAATTGGCGTGAAATTGTTGTTCAAGATAAA
AATGCAAATCGGAGGAGGAAATTTTATATCACACAACTGAAAACAGATTCTGAGGGGGCT
GTATTAAATGTCGAGGATGCTGCCACTCGGCTCCAGCTTTTAAATCGCTCAGCTTTAAGA
TCTGTGCAGGCACAGGCTAGGATACCTGGTTCTCAGAGAGAGCAAGGGTCAACATTATCT
CCCTGGGGAGAAGTTTTGACACCTCTAGCAAGCTCTTCTGTTACTCACTTAAGTAGTAAA
CAGGAAGAATATGTTAAGGTTGCCAAAACACTTTTTACTGATGAAGCATTAAAACCTTGC
CCAAGGTGCCAGTCCCCTGCTAAGTACCAGCCATATAAGAAAAGGGGACTGTGTAGCCGA
ACAGCCTGTGGTTTTGACTTTTGTGTGTTATGTCTGTGTGCTTATCATGGGTCTGAAGAA
TGTAGTAGAGGAGCAGCAAAGCCAAGAAATAGAAAAGATGCTCTCCCAGGAAGTGCCCAG
AGTAAGCGGAATTTAAAACGCCTCTGA
Protein Properties
Number of Residues 708
Molecular Weight 78401.5
Theoretical pI 8.15
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence 
>F-box only protein 43
MSFKDKDERISCLEAYVTLTSKSSRFTDETEILKMSQRHSGQAGTEAGNGADSPPIVNSK
YSTFRDFCSTSSFQDSGYNELKSCSFDNIDKEYLGKKEKGPTLLYEHPETSGLGLTHPLE
SPTQKKKCILPRKEKDKTPELCETPKISGKKCLPRRRLNVSFALLKGDFESQNSSLESSI
SQVINLEKNIPSSASGFSRANNFSPLVTSTLKTEEVTSCSQKLRLNFSQQKTSTIDDSKD
DCSLFEVECISPIQGNNFKDSITHDFSDSSLCINDENACPELLGSSVSGTTCGTDEDIFV
TPISNLVANIRFNASQILSPSPEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQ
KHKGTPKVGDTIRKTRHLGRSRRLSTLREQSSQSETEEEKQIVHPDSEKRAAAASAISEG
QLSSDESGDLTFSLKNLSKTPALQLVHELFMKSKRKRLQENSGHEFLEQGDGEKIAVLQC
ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCSVWKVSRNWREIVVQDK
NANRRRKFYITQLKTDSEGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLS
PWGEVLTPLASSSVTHLSSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSR
TACGFDFCVLCLCAYHGSEECSRGAAKPRNRKDALPGSAQSKRNLKRL
GenBank ID Protein 117606351
UniProtKB/Swiss-Prot ID Q4G163
UniProtKB/Swiss-Prot Entry Name FBX43_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_001029860.3
GeneCard ID FBXO43
GenAtlas ID FBXO43
HGNC ID HGNC:28521
References
General References
  1. Nusbaum C, Mikkelsen TS, Zody MC, Asakawa S, Taudien S, Garber M, Kodira CD, Schueler MG, Shimizu A, Whittaker CA, Chang JL, Cuomo CA, Dewar K, FitzGerald MG, Yang X, Allen NR, Anderson S, Asakawa T, Blechschmidt K, Bloom T, Borowsky ML, Butler J, Cook A, Corum B, DeArellano K, DeCaprio D, Dooley KT, Dorris L 3rd, Engels R, Glockner G, Hafez N, Hagopian DS, Hall JL, Ishikawa SK, Jaffe DB, Kamat A, Kudoh J, Lehmann R, Lokitsang T, Macdonald P, Major JE, Matthews CD, Mauceli E, Menzel U, Mihalev AH, Minoshima S, Murayama Y, Naylor JW, Nicol R, Nguyen C, O'Leary SB, O'Neill K, Parker SC, Polley A, Raymond CK, Reichwald K, Rodriguez J, Sasaki T, Schilhabel M, Siddiqui R, Smith CL, Sneddon TP, Talamas JA, Tenzin P, Topham K, Venkataraman V, Wen G, Yamazaki S, Young SK, Zeng Q, Zimmer AR, Rosenthal A, Birren BW, Platzer M, Shimizu N, Lander ES: DNA sequence and analysis of human chromosome 8. Nature. 2006 Jan 19;439(7074):331-5. [PubMed:16421571 ]
  2. Jin J, Cardozo T, Lovering RC, Elledge SJ, Pagano M, Harper JW: Systematic analysis and nomenclature of mammalian F-box proteins. Genes Dev. 2004 Nov 1;18(21):2573-80. [PubMed:15520277 ]
  3. Tung JJ, Hansen DV, Ban KH, Loktev AV, Summers MK, Adler JR 3rd, Jackson PK: A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4318-23. Epub 2005 Mar 7. [PubMed:15753281 ]
  4. Hansen DV, Tung JJ, Jackson PK: CaMKII and polo-like kinase 1 sequentially phosphorylate the cytostatic factor Emi2/XErp1 to trigger its destruction and meiotic exit. Proc Natl Acad Sci U S A. 2006 Jan 17;103(3):608-13. Epub 2006 Jan 9. [PubMed:16407128 ]