Hmdb loader
Identification
HMDB Protein ID HMDBP07456
Secondary Accession Numbers
  • 13164
Name Annexin A8
Synonyms
  1. Annexin VIII
  2. Annexin-8
  3. VAC-beta
  4. Vascular anticoagulant-beta
Gene Name ANXA8
Protein Type Unknown
Biological Properties
General Function Involved in calcium ion binding
Specific Function This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade
Pathways Not Available
Reactions Not Available
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
lipid binding
phospholipid binding
calcium-dependent phospholipid binding
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 10q11.22
SNPs ANXA8
Gene Sequence
>984 bp
ATGGCCTGGTGGAAATCCTGGATTGAACAGGAGGGTGTCACAGTGAAGAGCAGCTCCCAC
TTCAACCCAGACCCTGATGCAGAGACCCTCTACAAAGCCATGAAGGGGATCGGGACCAAC
GAGCAGGCTATCATCGATGTGCTCACCAAGAGAAGCAACACGCAGCGGCAGCAGATCGCC
AAGTCCTTCAAGGCTCAGTTCGGCAAGGACCTCACTGAGACCTTGAAGTCTGAGCTCAGT
GGCAAGTTTGAGAGGCTCATTGTGGCCCTTATGTACCCGCCATACAGATACGAAGCCAAG
GAGCTGCATGACGCCATGAAGGGCTTAGGAACCAAGGAGGGTGTCATCATTGAGATCCTG
GCCTCTCGGACCAAGAACCAGCTGCGGGAGATAATGAAGGCGTATGAGGAAGACTATGGG
TCCAGCCTGGAGGAGGACATCCAAGCAGACACAAGTGGCTACCTGGAGAGGATCCTGGTG
TGCCTCCTGCAGGGCAGCAGGGATGATGTGAGCAGCTTTGTGGACCCAGGACTGGCCCTC
CAAGACGCACAGGATCTGTATGCGGCAGGCGAGAAGATTCGTGGGACTGATGAGATGAAA
TTCATCACCATCCTGTGCACGCGCAGTGCCACTCACCTGCTGAGAGTGTTTGAAGAGTAT
GAGAAAATTGCCAACAAGAGCATTGAGGACAGCATCAAGAGTGAGACCCATGGCTCACTG
GAGGAGGCCATGCTCACTGTGGTGAAATGCACCCAAAACCTCCACAGCTACTTTGCAGAG
AGACTCTACTATGCCATGAAGGGAGCAGGGACGCGTGATGGGACCCTGATAAGAAACATC
GTTTCAAGGAGCGAGATTGACTTAAATCTTATCAAATGTCACTTCAAGAAGATGTACGGC
AAGACCCTCAGCAGCATGATCATGGAAGACACCAGCGGTGACTACAAGAACGCCCTGCTG
AGCCTGGTGGGCAGCGACCCCTGA
Protein Properties
Number of Residues 327
Molecular Weight 36880.6
Theoretical pI 5.51
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Annexin A8
MAWWKSWIEQEGVTVKSSSHFNPDPDAETLYKAMKGIGTNEQAIIDVLTKRSNTQRQQIA
KSFKAQFGKDLTETLKSELSGKFERLIVALMYPPYRYEAKELHDAMKGLGTKEGVIIEIL
ASRTKNQLREIMKAYEEDYGSSLEEDIQADTSGYLERILVCLLQGSRDDVSSFVDPGLAL
QDAQDLYAAGEKIRGTDEMKFITILCTRSATHLLRVFEEYEKIANKSIEDSIKSETHGSL
EEAMLTVVKCTQNLHSYFAERLYYAMKGAGTRDGTLIRNIVSRSEIDLNLIKCHFKKMYG
KTLSSMIMEDTSGDYKNALLSLVGSDP
GenBank ID Protein 55665641
UniProtKB/Swiss-Prot ID P13928
UniProtKB/Swiss-Prot Entry Name ANXA8_HUMAN
PDB IDs
GenBank Gene ID AL591684
GeneCard ID ANXA8
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Deloukas P, Earthrowl ME, Grafham DV, Rubenfield M, French L, Steward CA, Sims SK, Jones MC, Searle S, Scott C, Howe K, Hunt SE, Andrews TD, Gilbert JG, Swarbreck D, Ashurst JL, Taylor A, Battles J, Bird CP, Ainscough R, Almeida JP, Ashwell RI, Ambrose KD, Babbage AK, Bagguley CL, Bailey J, Banerjee R, Bates K, Beasley H, Bray-Allen S, Brown AJ, Brown JY, Burford DC, Burrill W, Burton J, Cahill P, Camire D, Carter NP, Chapman JC, Clark SY, Clarke G, Clee CM, Clegg S, Corby N, Coulson A, Dhami P, Dutta I, Dunn M, Faulkner L, Frankish A, Frankland JA, Garner P, Garnett J, Gribble S, Griffiths C, Grocock R, Gustafson E, Hammond S, Harley JL, Hart E, Heath PD, Ho TP, Hopkins B, Horne J, Howden PJ, Huckle E, Hynds C, Johnson C, Johnson D, Kana A, Kay M, Kimberley AM, Kershaw JK, Kokkinaki M, Laird GK, Lawlor S, Lee HM, Leongamornlert DA, Laird G, Lloyd C, Lloyd DM, Loveland J, Lovell J, McLaren S, McLay KE, McMurray A, Mashreghi-Mohammadi M, Matthews L, Milne S, Nickerson T, Nguyen M, Overton-Larty E, Palmer SA, Pearce AV, Peck AI, Pelan S, Phillimore B, Porter K, Rice CM, Rogosin A, Ross MT, Sarafidou T, Sehra HK, Shownkeen R, Skuce CD, Smith M, Standring L, Sycamore N, Tester J, Thorpe A, Torcasso W, Tracey A, Tromans A, Tsolas J, Wall M, Walsh J, Wang H, Weinstock K, West AP, Willey DL, Whitehead SL, Wilming L, Wray PW, Young L, Chen Y, Lovering RC, Moschonas NK, Siebert R, Fechtel K, Bentley D, Durbin R, Hubbard T, Doucette-Stamm L, Beck S, Smith DR, Rogers J: The DNA sequence and comparative analysis of human chromosome 10. Nature. 2004 May 27;429(6990):375-81. [PubMed:15164054 ]
  3. Hauptmann R, Maurer-Fogy I, Krystek E, Bodo G, Andree H, Reutelingsperger CP: Vascular anticoagulant beta: a novel human Ca2+/phospholipid binding protein that inhibits coagulation and phospholipase A2 activity. Its molecular cloning, expression and comparison with VAC-alpha. Eur J Biochem. 1989 Oct 20;185(1):63-71. [PubMed:2530088 ]
  4. Chang KS, Wang G, Freireich EJ, Daly M, Naylor SL, Trujillo JM, Stass SA: Specific expression of the annexin VIII gene in acute promyelocytic leukemia. Blood. 1992 Apr 1;79(7):1802-10. [PubMed:1313714 ]