| Identification |
|---|
| HMDB Protein ID
| HMDBP07376 |
| Secondary Accession Numbers
| |
| Name
| Dihydrofolate reductase |
| Synonyms
|
- SubName: cDNA, FLJ93028, Homo sapiens dihydrofolate reductase (DHFR), mRNA
|
| Gene Name
| DYR |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in dihydrofolate reductase activity |
| Specific Function
| Not Available |
| Pathways
|
- One carbon pool by folate
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| nucleotide binding |
| dihydrofolate reductase activity |
| oxidoreductase activity, acting on the ch-nh group of donors, nad or nadp as acceptor |
| nadp or nadph binding |
| oxidoreductase activity, acting on the ch-nh group of donors |
| oxidoreductase activity |
| binding |
| catalytic activity |
| Process |
| cellular amino acid metabolic process |
| glycine biosynthetic process |
| nucleotide biosynthetic process |
| glycine metabolic process |
| serine family amino acid metabolic process |
| metabolic process |
| nitrogen compound metabolic process |
| nucleobase, nucleoside, nucleotide and nucleic acid metabolic process |
| cellular amino acid and derivative metabolic process |
| oxidation reduction |
| cellular nitrogen compound metabolic process |
| cellular metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| nucleobase, nucleoside and nucleotide metabolic process |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| DYR |
| Gene Sequence
|
>564 bp
ATGGTTGGTTCGCTAAACTGCATCGTCGCTGTGTCCCAGAACATGGGCATCGGCAAGAAC
GGGGACCTGCCCTGGCCACCGCTCAGGAATGAATTCAGATATTTCCAGAGAATGACCACA
ACCTCTTCAGTAGAAGGTAAACAGAATCTGGTGATTATGGGTAAGAAGACCTGGTTCTCC
ATTCCTGAGAAGAATCGACCTTTAAAGGGTAGAATTAATTTAGTTCTCAGCAGAGAACTC
AAGGAACCTCCACAAGGAGCTCATTTTCTTTCCAGAAGTCTAGATGATGCCTTAAAACTT
ACTGAACAACCAGAATTAGCAAATAAAGTAGACATGGTCTGGATAGTTGGTGGCAGTTCT
GTTTATAAGGAAGCCATGAATCACCCAGGCCATCTTAAACTATTTGTGACAAGGATCATG
CAAGACTTTGAAAGTGACACGTTTTTTCCAGAAATTGATTTGGAGAAATATAAACTTCTG
CCAGAATACCCAGGTGTTCTCTCTGATGTCCAGGAGGAGAAAGGCATTAAGTACAAATTT
GAAGTATATGAGAAGAATGATTAA
|
| Protein Properties |
|---|
| Number of Residues
| 187 |
| Molecular Weight
| 21452.6 |
| Theoretical pI
| 7.6 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dihydrofolate reductase
MVGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFS
IPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSS
VYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKF
EVYEKND
|
| External Links |
|---|
| GenBank ID Protein
| 189069188 |
| UniProtKB/Swiss-Prot ID
| B0YJ76 |
| UniProtKB/Swiss-Prot Entry Name
| B0YJ76_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AK312642 |
| GeneCard ID
| DYR |
| GenAtlas ID
| DYR |
| HGNC ID
| HGNC:2861 |
| References |
|---|
| General References
| - Kao TT, Wang KC, Chang WN, Lin CY, Chen BH, Wu HL, Shi GY, Tsai JN, Fu TF: Characterization and comparative studies of zebrafish and human recombinant dihydrofolate reductases--inhibition by folic acid and polyphenols. Drug Metab Dispos. 2008 Mar;36(3):508-16. Epub 2007 Dec 3. [PubMed:18056255 ]
|
