| Identification |
|---|
| HMDB Protein ID
| HMDBP01820 |
| Secondary Accession Numbers
| |
| Name
| Proprotein convertase subtilisin/kexin type 6 |
| Synonyms
|
- Paired basic amino acid cleaving enzyme 4
- SPC4
- Subtilisin-like proprotein convertase 4
- Subtilisin/kexin-like protease PACE4
|
| Gene Name
| PCSK6 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Involved in serine-type endopeptidase activity |
| Specific Function
| Likely to represent an endoprotease activity within the constitutive secretory pathway, with unique restricted distribution in both neuroendocrine and non-neuroendocrine tissues and capable of cleavage at the RX(K/R)R consensus motif |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Function |
| catalytic activity |
| hydrolase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| endopeptidase activity |
| serine-type endopeptidase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Isoform PACE4B:Secreted
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 15q26.3 |
| SNPs
| PCSK6 |
| Gene Sequence
|
>2910 bp
ATGCCTCCGCGCGCGCCGCCTGCGCCCGGGCCCCGGCCGCCGCCCCGGGCCGCCGCCGCC
ACCGACACCGCCGCGGGCGCGGGGGGCGCGGGGGGCGCGGGGGGCGCCGGCGGGCCCGGG
TTCCGGCCGCTCGCGCCGCGTCCCTGGCGCTGGCTGCTGCTGCTGGCGCTGCCTGCCGCC
TGCTCCGCGCCCCCGCCGCGCCCCGTCTACACCAACCACTGGGCGGTGCAAGTGCTGGGC
GGCCCGGCCGAGGCGGACCGCGTGGCGGCGGCGCACGGGTACCTCAACTTGGGCCAGATT
GGAAACCTGGAAGATTACTACCATTTTTATCACAGCAAAACCTTTAAAAGATCAACCTTG
AGTAGCAGAGGCCCTCACACCTTCCTCAGAATGGACCCCCAGGTGAAATGGCTCCAGCAA
CAGGAAGTGAAACGAAGGGTGAAGAGACAGGTGCGAAGTGACCCGCAGGCCCTTTACTTC
AACGACCCCATTTGGTCCAACATGTGGTACCTGCATTGTGGCGACAAGAACAGTCGCTGC
CGGTCGGAAATGAATGTCCAGGCAGCGTGGAAGAGGGGCTACACAGGAAAAAACGTGGTG
GTCACCATCCTTGATGATGGCATAGAGAGAAATCACCCTGACCTGGCCCCAAATTATGAT
TCCTACGCCAGCTACGACGTGAACGGCAATGATTATGACCCATCTCCACGATATGATGCC
AGCAATGAAAATAAACACGGCACTCGTTGTGCGGGAGAAGTTGCTGCTTCAGCAAACAAT
TCCTACTGCATCGTGGGCATAGCGTACAATGCCAAAATAGGAGGCATCCGCATGCTGGAC
GGCGATGTCACAGATGTGGTCGAGGCAAAGTCGCTGGGCATCAGACCCAACTACATCGAC
ATTTACAGTGCCAGCTGGGGGCCGGACGACGACGGCAAGACGGTGGACGGGCCCGGCCGA
CTGGCTAAGCAGGCTTTCGAGTATGGCATTAAAAAGGGCCGGCAGGGCCTGGGCTCCATT
TTCGTCTGGGCATCTGGGAATGGCGGGAGAGAGGGGGACTACTGCTCGTGCGATGGCTAC
ACCAACAGCATCTACACCATCTCCGTCAGCAGCGCCACCGAGAATGGCTACAAGCCCTGG
TACCTGGAAGAGTGTGCCTCCACCCTGGCCACCACCTACAGCAGTGGGGCCTTTTATGAG
CGAAAAATCGTCACCACGGATCTGCGTCAGCGCTGTACCGATGGCCACACTGGGACCTCA
GTCTCTGCCCCCATGGTGGCGGGCATCATCGCCTTGGCTCTAGAAGCAAACAGCCAGTTA
ACCTGGAGGGACGTCCAGCACCTGCTAGTGAAGACATCCCGGCCGGCCCACCTGAAAGCG
AGCGACTGGAAAGTGAACGGCGCGGGTCATAAAGTTAGCCATTTCTATGGATTTGGTTTG
GTGGACGCAGAAGCTCTCGTTGTGGAGGCAAAGAAGTGGACAGCAGTGCCATCGCAGCAC
ATGTGCGTGGCCGCCTCGGACAAGAGACCCAGGAGCATCCCCTTAGTGCAGGTGCTGCGG
ACTACGGCCCTGACCAGCGCCTGCGCGGAGCACTCGGACCAGCGGGTGGTCTACTTGGAG
CACGTGGTGGTTCGCACCTCCATCTCACACCCACGCCGAGGAGACCTCCAGATCTACCTG
GTTTCTCCCTCGGGAACCAAGTCTCAACTTTTGGCAAAGAGGTTGCTGGATCTTTCCAAT
GAAGGGTTTACAAACTGGGAATTCATGACTGTCCACTGCTGGGGAGAAAAGGCTGAAGGG
CAGTGGACCTTGGAAATCCAAGATCTGCCATCCCAGGTCCGCAACCCGGAGAAGCAAGGG
AAGTTGAAAGAATGGAGCCTCATACTGTATGGCACAGCAGAGCACCCGTACCACATCTTC
AGTGCCCATCAGTCCCGCTCGCGGATGCTGGAGCTCTCAGCCCCAGAGCTGGAGCCACCC
AAGGCTGCCCTGTCACCCTCCCAGGTGGAAGTTCCTGAAGATGAGGAAGATTACACAGCT
CAATCCACCCCAGGCTCTGCTAATATTTTACAGACCAGTGTGTGCCATCCGGAGTGTGGT
GACAAAGGCTGTGATGGCCCCAATGCAGACCAGTGCTTGAACTGCGTCCACTTCAGCCTG
GGGAGTGTCAAGACCAGCAGGAAGTGCGTGAGTGTGTGCCCCTTGGGCTACTTTGGGGAC
ACAGCAGCAAGACGCTGTCGCCGGTGCCACAAGGGGTGTGAGACCTGCTCCAGCAGAGCT
GCGACGCAGTGCCTGTCTTGCCGCCGCGGGTTCTATCACCACCAGGAGATGAACACCTGT
GTGACCCTCTGTCCTGCAGGATTTTATGCTGATGAAAGTCAGAAAAATTGCCTTAAATGC
CACCCAAGCTGTAAAAAGTGCGTGGATGAACCTGAGAAATGTACTGTCTGTAAAGAAGGA
TTCAGCCTTGCACGGGGCAGCTGCATTCCTGACTGTGAGCCAGGCACCTACTTTGACTCA
GAGCTGATCAGATGTGGGGAATGCCATCACACCTGCGGAACCTGCGTGGGGCCAGGCAGA
GAAGAGTGCATTCACTGTGCGAAAAACTTCCACTTCCACGACTGGAAGTGTGTGCCAGCC
TGTGGTGAGGGCTTCTACCCAGAAGAGATGCCGGGCTTGCCCCACAAAGTGTGTCGAAGG
TGTGACGAGAACTGCTTGAGCTGTGCAGGCTCCAGCAGGAACTGTAGCAGGTGTAAGACG
GGCTTCACACAGCTGGGGACCTCCTGCATCACCAACCACACGTGCAGCAACGCTGACGAG
ACATTCTGCGAGATGGTGAAGTCCAACCGGCTGTGCGAACGGAAGCTCTTCATTCAGTTC
TGCTGCCGCACGTGCCTCCTGGCCGGGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 969 |
| Molecular Weight
| 106419.2 |
| Theoretical pI
| 7.7 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Proprotein convertase subtilisin/kexin type 6
MPPRAPPAPGPRPPPRAAAATDTAAGAGGAGGAGGAGGPGFRPLAPRPWRWLLLLALPAA
CSAPPPRPVYTNHWAVQVLGGPAEADRVAAAHGYLNLGQIGNLEDYYHFYHSKTFKRSTL
SSRGPHTFLRMDPQVKWLQQQEVKRRVKRQVRSDPQALYFNDPIWSNMWYLHCGDKNSRC
RSEMNVQAAWKRGYTGKNVVVTILDDGIERNHPDLAPNYDSYASYDVNGNDYDPSPRYDA
SNENKHGTRCAGEVAASANNSYCIVGIAYNAKIGGIRMLDGDVTDVVEAKSLGIRPNYID
IYSASWGPDDDGKTVDGPGRLAKQAFEYGIKKGRQGLGSIFVWASGNGGREGDYCSCDGY
TNSIYTISVSSATENGYKPWYLEECASTLATTYSSGAFYERKIVTTDLRQRCTDGHTGTS
VSAPMVAGIIALALEANSQLTWRDVQHLLVKTSRPAHLKASDWKVNGAGHKVSHFYGFGL
VDAEALVVEAKKWTAVPSQHMCVAASDKRPRSIPLVQVLRTTALTSACAEHSDQRVVYLE
HVVVRTSISHPRRGDLQIYLVSPSGTKSQLLAKRLLDLSNEGFTNWEFMTVHCWGEKAEG
QWTLEIQDLPSQVRNPEKQGKLKEWSLILYGTAEHPYHTFSAHQSRSRMLELSAPELEPP
KAALSPSQVEVPEDEEDYTAQSTPGSANILQTSVCHPECGDKGCDGPNADQCLNCVHFSL
GSVKTSRKCVSVCPLGYFGDTAARRCRRCHKGCETCSSRAATQCLSCRRGFYHHQEMNTC
VTLCPAGFYADESQKNCLKCHPSCKKCVDEPEKCTVCKEGFSLARGSCIPDCEPGTYFDS
ELIRCGECHHTCGTCVGPGREECIHCAKNFHFHDWKCVPACGEGFYPEEMPGLPHKVCRR
CDENCLSCAGSSRNCSRCKTGFTQLGTSCITNHTCSNADETFCEMVKSNRLCERKLFIQF
CCRTCLLAG
|
| External Links |
|---|
| GenBank ID Protein
| 2281775 |
| UniProtKB/Swiss-Prot ID
| P29122 |
| UniProtKB/Swiss-Prot Entry Name
| PCSK6_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB001914 |
| GeneCard ID
| PCSK6 |
| GenAtlas ID
| PCSK6 |
| HGNC ID
| HGNC:8569 |
| References |
|---|
| General References
| - Kiefer MC, Tucker JE, Joh R, Landsberg KE, Saltman D, Barr PJ: Identification of a second human subtilisin-like protease gene in the fes/fps region of chromosome 15. DNA Cell Biol. 1991 Dec;10(10):757-69. [PubMed:1741956 ]
- Tsuji A, Higashine K, Hine C, Mori K, Tamai Y, Nagamune H, Matsuda Y: Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms. Biochem Biophys Res Commun. 1994 Apr 29;200(2):943-50. [PubMed:8179631 ]
- Tsuji A, Higashine K, Hine C, Mori K, Tamai Y, Nagamune H, Matsuda Y: "Identification of novel cDNAs encoding human kexin-like protease, PACE4 isoforms.". Biochem Biophys Res Commun. 1994 Nov 15;204(3):1381-2. [PubMed:7980617 ]
- Mori K, Kii S, Tsuji A, Nagahama M, Imamaki A, Hayashi K, Akamatsu T, Nagamune H, Matsuda Y: A novel human PACE4 isoform, PACE4E is an active processing protease containing a hydrophobic cluster at the carboxy terminus. J Biochem. 1997 May;121(5):941-8. [PubMed:9192737 ]
- Tsuji A, Hine C, Tamai Y, Yonemoto K, Mori K, Yoshida S, Bando M, Sakai E, Mori K, Akamatsu T, Matsuda Y: Genomic organization and alternative splicing of human PACE4 (SPC4), kexin-like processing endoprotease. J Biochem. 1997 Aug;122(2):438-52. [PubMed:9378725 ]
- Zhong M, Benjannet S, Lazure C, Munzer S, Seidah NG: Functional analysis of human PACE4-A and PACE4-C isoforms: identification of a new PACE4-CS isoform. FEBS Lett. 1996 Oct 28;396(1):31-6. [PubMed:8906861 ]
- Sucic JF, Moehring JM, Inocencio NM, Luchini JW, Moehring TJ: Endoprotease PACE4 is Ca2+-dependent and temperature-sensitive and can partly rescue the phenotype of a furin-deficient cell strain. Biochem J. 1999 May 1;339 ( Pt 3):639-47. [PubMed:10215603 ]
- Nagahama M, Taniguchi T, Hashimoto E, Imamaki A, Mori K, Tsuji A, Matsuda Y: Biosynthetic processing and quaternary interactions of proprotein convertase SPC4 (PACE4). FEBS Lett. 1998 Aug 28;434(1-2):155-9. [PubMed:9738469 ]
|
