Hmdb loader
Identification
HMDB Protein ID HMDBP01539
Secondary Accession Numbers
  • 6835
Name Serine/threonine-protein kinase H1
Synonyms
  1. PSK-H1
  2. Protein serine kinase H1
Gene Name PSKH1
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function May be a SFC-associated serine kinase (splicing factor compartment-associated serine kinase) with a role in intranuclear SR protein (non-snRNP splicing factors containing a serine/arginine-rich domain) trafficking and pre-mRNA processing
Pathways Not Available
Reactions Not Available
GO Classification
Function
adenyl ribonucleotide binding
protein serine/threonine kinase activity
protein kinase activity
atp binding
binding
adenyl nucleotide binding
purine nucleoside binding
nucleoside binding
kinase activity
transferase activity, transferring phosphorus-containing groups
transferase activity
catalytic activity
Process
cellular metabolic process
phosphorus metabolic process
phosphate metabolic process
phosphorylation
metabolic process
protein amino acid phosphorylation
Cellular Location
  1. Cell membrane
  2. Lipid-anchor
  3. Lipid-anchor
  4. Cytoplasm
  5. Cytoplasm
  6. Endoplasmic reticulum membrane
  7. Golgi apparatus
  8. cytoskeleton
  9. Nucleus speckle
  10. centrosome
Gene Properties
Chromosome Location Chromosome:1
Locus 16q22.1
SNPs PSKH1
Gene Sequence
>1275 bp
ATGGGCTGTGGGACAAGCAAGGTCCTTCCCGAGCCACCCAAGGATGTCCAGCTGGATCTG
GTCAAGAAGGTGGAGCCCTTCAGTGGCACTAAGAGTGACGTGTACAAGCACTTCATCACA
GAGGTGGACAGTGTTGGCCCTGTCAAAGCCGGGTTCCCAGCAGCAAGTCAGTATGCACAC
CCCTGCCCCGGTCCCCCGACTGCTGGCCACACGGAGCCTCCCTCAGAACCACCACGCAGG
GCCAGGGTAGCTAAGTACAGGGCCAAGTTTGACCCACGTGTTACAGCTAAGTATGACATC
AAGGCCCTAATTGGCCGAGGCAGCTTCAGCCGAGTGGTACGTGTAGAGCACCGGGCAACC
CGGCAGCCGTATGCCATCAAGATGATTGAGACCAAGTACCGGGAGGGGCGGGAGGTGTGT
GAGTCGGAGCTGCGTGTGCTGCGTCGGGTGCGTCATGCCAACATCATCCAGCTGGTGGAG
GTGTTCGAGACACAGGAGCGGGTGTACATGGTGATGGAGCTGGCCACTGGTGGAGAGCTC
TTTGACCGCATCATTGCCAAGGGCTCCTTCACCGAGCGTGACGCCACGCGGGTGCTGCAG
ATGGTGCTGGATGGCGTCCGGTATCTGCATGCACTGGGCATCACACACCGAGACCTCAAA
CCTGAGAATCTGCTCTACTACCATCCGGGCACTGACTCCAAGATCATCATCACCGACTTC
GGCCTGGCCAGTGCTCGCAAGAAGGGTGATGACTGCTTGATGAAGACCACCTGTGGCACG
CCTGAGTACATTGCCCCAGAAGTCCTGGTCCGCAAGCCATACACCAACTCAGTGGACATG
TGGGCGCTGGGCGTCATTGCCTACATCCTACTCAGTGGCACCATGCCGTTTGAGGATGAC
AACCGTACCCGGCTGTACCGGCAGATCCTCAGGGGCAAGTACAGTTACTCTGGGGAGCCC
TGGCCTAGTGTGTCCAACCTGGCCAAGGACTTCATTGACCGCCTGCTGACAGTGGACCCT
GGAGCCCGTATGACTGCACTGCAGGCCCTGAGGCACCCGTGGGTGGTGAGCATGGCTGCC
TCTTCATCCATGAAGAACCTGCACCGCTCCATATCCCAGAACCTCCTTAAACGTGCCTCC
TCGCGCTGCCAGAGCACCAAATCTGCCCAGTCCACGCGTTCCAGCCGCTCCACACGCTCC
AATAAGTCACGCCGTGTGCGGGAACGGGAGCTGCGGGAGCTCAACCTGCGCTACCAGCAG
CAATACAATGGCTGA
Protein Properties
Number of Residues 424
Molecular Weight 48034.7
Theoretical pI 10.28
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Serine/threonine-protein kinase H1
MGCGTSKVLPEPPKDVQLDLVKKVEPFSGTKSDVYKHFITEVDSVGPVKAGFPAASQYAH
PCPGPPTAGHTEPPSEPPRRARVAKYRAKFDPRVTAKYDIKALIGRGSFSRVVRVEHRAT
RQPYAIKMIETKYREGREVCESELRVLRRVRHANIIQLVEVFETQERVYMVMELATGGEL
FDRIIAKGSFTERDATRVLQMVLDGVRYLHALGITHRDLKPENLLYYHPGTDSKIIITDF
GLASARKKGDDCLMKTTCGTPEYIAPEVLVRKPYTNSVDMWALGVIAYILLSGTMPFEDD
NRTRLYRQILRGKYSYSGEPWPSVSNLAKDFIDRLLTVDPGARMTALQALRHPWVVSMAA
SSSMKNLHRSISQNLLKRASSRCQSTKSAQSTRSSRSTRSNKSRRVRERELRELNLRYQQ
QYNG
GenBank ID Protein 7981277
UniProtKB/Swiss-Prot ID P11801
UniProtKB/Swiss-Prot Entry Name KPSH1_HUMAN
PDB IDs Not Available
GenBank Gene ID AJ272212
GeneCard ID PSKH1
GenAtlas ID PSKH1
HGNC ID HGNC:9529
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  3. Hanks SK: Homology probing: identification of cDNA clones encoding members of the protein-serine kinase family. Proc Natl Acad Sci U S A. 1987 Jan;84(2):388-92. [PubMed:2948189 ]
  4. Brede G, Solheim J, Troen G, Prydz H: Characterization of PSKH1, a novel human protein serine kinase with centrosomal, golgi, and nuclear localization. Genomics. 2000 Nov 15;70(1):82-92. [PubMed:11087665 ]
  5. Brede G, Solheim J, Prydz H: PSKH1, a novel splice factor compartment-associated serine kinase. Nucleic Acids Res. 2002 Dec 1;30(23):5301-9. [PubMed:12466556 ]
  6. Brede G, Solheim J, Stang E, Prydz H: Mutants of the protein serine kinase PSKH1 disassemble the Golgi apparatus. Exp Cell Res. 2003 Dec 10;291(2):299-312. [PubMed:14644153 ]