Hmdb loader
Identification
HMDB Protein ID HMDBP01488
Secondary Accession Numbers
  • 6784
Name Cell division protein kinase 18
Synonyms
  1. PCTAIRE-motif protein kinase 3
  2. Serine/threonine-protein kinase PCTAIRE-3
Gene Name CDK18
Protein Type Enzyme
Biological Properties
General Function Involved in protein kinase activity
Specific Function May play a role in signal transduction cascades in terminally differentiated cells
Pathways Not Available
Reactions Not Available
GO Classification
Function
adenyl ribonucleotide binding
protein serine/threonine kinase activity
protein kinase activity
atp binding
binding
adenyl nucleotide binding
purine nucleoside binding
nucleoside binding
kinase activity
transferase activity, transferring phosphorus-containing groups
transferase activity
catalytic activity
Process
cellular metabolic process
phosphorus metabolic process
phosphate metabolic process
phosphorylation
metabolic process
protein amino acid phosphorylation
Cellular Location Not Available
Gene Properties
Chromosome Location Chromosome:1
Locus 1q31-q32
SNPs CDK18
Gene Sequence
>1419 bp
ATGAACAAGATGAAGAACTTTAAGCGCCGTTTCTCCCTGTCAGTGCCCCGCACTGAGACC
ATTGAAGAATCCTTGGCTGAATTCACGGAGCAATTCAACCAGCTCCACAACCGGCGGAAT
GAGAACTTGCAGCTCGGTCCTCTTGGCAGAGACCCCCCGCAGGAGTGCAGCACCTTCTCC
CCAACAGACAGCGGGGAGGAGCCGGGGCAGCTCTCCCCTGGCGTGCAGTTCCAGCGGCGG
CAGAACCAGCGCCGCTTCTCCATGGAGGACGTCAGCAAGAGGCTCTCTCTGCCCATGGAT
ATCCGCCTGCCCCAGGAATTCCTACAGAAGCTACAGATGGAGAGCCCAGATCTGCCCAAG
CCGCTCAGCCGCATGTCCCGCCGGGCCTCCCTGTCAGACATTGGCTTTGGGAAACTGGAA
ACATACGTGAAACTGGACAAACTGGGAGAGGGCACCTATGCCACAGTCTTCAAAGGGCGC
AGCAAACTGACGGAGAACCTTGTGGCCCTGAAAGAGATCCGGCTGGAGCACGAGGAGGGA
GCGCCCTGCACTGCCATCCGAGAGGTGTCTCTGCTGAAGAACCTGAAGCACGCCAATATT
GTGACCCTGCATGACCTCATCCACACAGATCGGTCCCTCACCCTGGTGTTTGAGTACCTG
GACAGTGACCTGAAGCAGTATCTGGACCACTGTGGGAACCTCATGAGCATGCACAACGTC
AAGATTTTCATGTTCCAGCTGCTCCGGGGCCTCGCCTACTGTCACCACCGCAAGATCCTG
CACCGGGACCTGAAGCCCCAGAACCTGCTCATCAACGAGAGGGGGGAGCTGAAGCTGGCC
GACTTTGGACTGGCCAGGGCCAAGTCAGTGCCCACAAAGACTTACTCCAATGAGGTGGTG
ACCCTGTGGTACAGGCCCCCCGATGTGCTGCTGGGATCCACAGAGTACTCCACCCCCATT
GATATGTGGGGCGTGGGCTGCATCCACTACGAGATGGCCACAGGGAGGCCCCTCTTCCCG
GGCTCCACAGTCAAGGAGGAGCTGCACCTCATCTTTCGCCTCCTCGGGACCCCCACAGAA
GAGACGTGGCCCGGCGTGACCGCCTTCTCTGAGTTCCGCACCTACAGCTTCCCCTGCTAC
CTCCCGCAGCCGCTCATCAACCACGCGCCCAGGTTGGATACGGATGGCATCCACCTCCTG
AGCAGCCTGCTCCTGTATGAATCCAAGAGTCGCATGTCAGCAGAGGCTGCCCTGAGTCAC
TCCTACTTCCGGTCTCTGGGAGAGCGTGTGCACCAGCTTGAAGACACTGCCTCCATCTTC
TCCCTGAAGGAGATCCAGCTCCAGAAGGACCCAGGCTACCGAGGCTTGGCCTTCCAGCAG
CCAGGACGAGGGAAGAACAGGCGGCAGAGCATCTTCTGA
Protein Properties
Number of Residues 472
Molecular Weight 54179.6
Theoretical pI 8.89
Pfam Domain Function
Signals
  • None
Transmembrane Regions
  • None
Protein Sequence
>Cell division protein kinase 18
MNKMKNFKRRFSLSVPRTETIEESLAEFTEQFNQLHNRRNENLQLGPLGRDPPQECSTFS
PTDSGEEPGQLSPGVQFQRRQNQRRFSMEDVSKRLSLPMDIRLPQEFLQKLQMESPDLPK
PLSRMSRRASLSDIGFGKLETYVKLDKLGEGTYATVFKGRSKLTENLVALKEIRLEHEEG
APCTAIREVSLLKNLKHANIVTLHDLIHTDRSLTLVFEYLDSDLKQYLDHCGNLMSMHNV
KIFMFQLLRGLAYCHHRKILHRDLKPQNLLINERGELKLADFGLARAKSVPTKTYSNEVV
TLWYRPPDVLLGSTEYSTPIDMWGVGCIHYEMATGRPLFPGSTVKEELHLIFRLLGTPTE
ETWPGVTAFSEFRTYSFPCYLPQPLINHAPRLDTDGIHLLSSLLLYESKSRMSAEAALSH
SYFRSLGERVHQLEDTASIFSLKEIQLQKDPGYRGLAFQQPGRGKNRRQSIF
GenBank ID Protein 55664790
UniProtKB/Swiss-Prot ID Q07002
UniProtKB/Swiss-Prot Entry Name CDK18_HUMAN
PDB IDs Not Available
GenBank Gene ID AL357131
GeneCard ID CDK18
GenAtlas ID CDK18
HGNC ID HGNC:8751
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Gregory SG, Barlow KF, McLay KE, Kaul R, Swarbreck D, Dunham A, Scott CE, Howe KL, Woodfine K, Spencer CC, Jones MC, Gillson C, Searle S, Zhou Y, Kokocinski F, McDonald L, Evans R, Phillips K, Atkinson A, Cooper R, Jones C, Hall RE, Andrews TD, Lloyd C, Ainscough R, Almeida JP, Ambrose KD, Anderson F, Andrew RW, Ashwell RI, Aubin K, Babbage AK, Bagguley CL, Bailey J, Beasley H, Bethel G, Bird CP, Bray-Allen S, Brown JY, Brown AJ, Buckley D, Burton J, Bye J, Carder C, Chapman JC, Clark SY, Clarke G, Clee C, Cobley V, Collier RE, Corby N, Coville GJ, Davies J, Deadman R, Dunn M, Earthrowl M, Ellington AG, Errington H, Frankish A, Frankland J, French L, Garner P, Garnett J, Gay L, Ghori MR, Gibson R, Gilby LM, Gillett W, Glithero RJ, Grafham DV, Griffiths C, Griffiths-Jones S, Grocock R, Hammond S, Harrison ES, Hart E, Haugen E, Heath PD, Holmes S, Holt K, Howden PJ, Hunt AR, Hunt SE, Hunter G, Isherwood J, James R, Johnson C, Johnson D, Joy A, Kay M, Kershaw JK, Kibukawa M, Kimberley AM, King A, Knights AJ, Lad H, Laird G, Lawlor S, Leongamornlert DA, Lloyd DM, Loveland J, Lovell J, Lush MJ, Lyne R, Martin S, Mashreghi-Mohammadi M, Matthews L, Matthews NS, McLaren S, Milne S, Mistry S, Moore MJ, Nickerson T, O'Dell CN, Oliver K, Palmeiri A, Palmer SA, Parker A, Patel D, Pearce AV, Peck AI, Pelan S, Phelps K, Phillimore BJ, Plumb R, Rajan J, Raymond C, Rouse G, Saenphimmachak C, Sehra HK, Sheridan E, Shownkeen R, Sims S, Skuce CD, Smith M, Steward C, Subramanian S, Sycamore N, Tracey A, Tromans A, Van Helmond Z, Wall M, Wallis JM, White S, Whitehead SL, Wilkinson JE, Willey DL, Williams H, Wilming L, Wray PW, Wu Z, Coulson A, Vaudin M, Sulston JE, Durbin R, Hubbard T, Wooster R, Dunham I, Carter NP, McVean G, Ross MT, Harrow J, Olson MV, Beck S, Rogers J, Bentley DR, Banerjee R, Bryant SP, Burford DC, Burrill WD, Clegg SM, Dhami P, Dovey O, Faulkner LM, Gribble SM, Langford CF, Pandian RD, Porter KM, Prigmore E: The DNA sequence and biological annotation of human chromosome 1. Nature. 2006 May 18;441(7091):315-21. [PubMed:16710414 ]
  3. Dephoure N, Zhou C, Villen J, Beausoleil SA, Bakalarski CE, Elledge SJ, Gygi SP: A quantitative atlas of mitotic phosphorylation. Proc Natl Acad Sci U S A. 2008 Aug 5;105(31):10762-7. doi: 10.1073/pnas.0805139105. Epub 2008 Jul 31. [PubMed:18669648 ]
  4. Daub H, Olsen JV, Bairlein M, Gnad F, Oppermann FS, Korner R, Greff Z, Keri G, Stemmann O, Mann M: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. Mol Cell. 2008 Aug 8;31(3):438-48. doi: 10.1016/j.molcel.2008.07.007. [PubMed:18691976 ]
  5. Oppermann FS, Gnad F, Olsen JV, Hornberger R, Greff Z, Keri G, Mann M, Daub H: Large-scale proteomics analysis of the human kinome. Mol Cell Proteomics. 2009 Jul;8(7):1751-64. doi: 10.1074/mcp.M800588-MCP200. Epub 2009 Apr 15. [PubMed:19369195 ]
  6. Yu LR, Zhu Z, Chan KC, Issaq HJ, Dimitrov DS, Veenstra TD: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra. J Proteome Res. 2007 Nov;6(11):4150-62. Epub 2007 Oct 9. [PubMed:17924679 ]
  7. Greenman C, Stephens P, Smith R, Dalgliesh GL, Hunter C, Bignell G, Davies H, Teague J, Butler A, Stevens C, Edkins S, O'Meara S, Vastrik I, Schmidt EE, Avis T, Barthorpe S, Bhamra G, Buck G, Choudhury B, Clements J, Cole J, Dicks E, Forbes S, Gray K, Halliday K, Harrison R, Hills K, Hinton J, Jenkinson A, Jones D, Menzies A, Mironenko T, Perry J, Raine K, Richardson D, Shepherd R, Small A, Tofts C, Varian J, Webb T, West S, Widaa S, Yates A, Cahill DP, Louis DN, Goldstraw P, Nicholson AG, Brasseur F, Looijenga L, Weber BL, Chiew YE, DeFazio A, Greaves MF, Green AR, Campbell P, Birney E, Easton DF, Chenevix-Trench G, Tan MH, Khoo SK, Teh BT, Yuen ST, Leung SY, Wooster R, Futreal PA, Stratton MR: Patterns of somatic mutation in human cancer genomes. Nature. 2007 Mar 8;446(7132):153-8. [PubMed:17344846 ]
  8. Meyerson M, Enders GH, Wu CL, Su LK, Gorka C, Nelson C, Harlow E, Tsai LH: A family of human cdc2-related protein kinases. EMBO J. 1992 Aug;11(8):2909-17. [PubMed:1639063 ]
  9. Wissing J, Jansch L, Nimtz M, Dieterich G, Hornberger R, Keri G, Wehland J, Daub H: Proteomics analysis of protein kinases by target class-selective prefractionation and tandem mass spectrometry. Mol Cell Proteomics. 2007 Mar;6(3):537-47. Epub 2006 Dec 27. [PubMed:17192257 ]
  10. Herskovits AZ, Davies P: Cloning and expression analysis of two novel PCTAIRE 3 transcripts from human brain. Gene. 2004 Mar 17;328:59-67. [PubMed:15019984 ]