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Showing Protein Guanylate cyclase soluble subunit beta-1 (HMDBP01064)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 7 metabolites
Identification
HMDB Protein ID HMDBP01064
Secondary Accession Numbers
  • 6353
Name Guanylate cyclase soluble subunit beta-1
Synonyms
  1. GCS-beta-1
  2. GCS-beta-3
  3. Guanylate cyclase soluble subunit beta-3
  4. Soluble guanylate cyclase small subunit
Gene Name GUCY1B3
Protein Type Unknown
Biological Properties
General Function Involved in phosphorus-oxygen lyase activity
Specific Function Not Available
Pathways
  • Adenine phosphoribosyltransferase deficiency (APRT)
  • Adenosine Deaminase Deficiency
  • Adenylosuccinate Lyase Deficiency
  • AICA-Ribosiduria
  • Azathioprine Action Pathway
  • Circadian entrainment
  • Gap junction
  • Gout or Kelley-Seegmiller Syndrome
  • Lesch-Nyhan Syndrome (LNS)
  • Long-term depression
  • Mercaptopurine Action Pathway
  • Mitochondrial DNA depletion syndrome
  • Molybdenum Cofactor Deficiency
  • Myoadenylate deaminase deficiency
  • Purine metabolism
  • Purine metabolism
  • Purine Nucleoside Phosphorylase Deficiency
  • Salivary secretion
  • Thioguanine Action Pathway
  • Vascular smooth muscle contraction
  • Xanthine Dehydrogenase Deficiency (Xanthinuria)
  • Xanthinuria type I
  • Xanthinuria type II
Reactions
Guanosine triphosphate → Cyclic GMP + Pyrophosphate details
GO Classification
Biological Process
nitric oxide mediated signal transduction
blood circulation
blood coagulation
Cellular Component
guanylate cyclase complex, soluble
intracellular membrane-bounded organelle
Function
cation binding
guanylate cyclase activity
phosphorus-oxygen lyase activity
cyclase activity
heme binding
iron ion binding
lyase activity
ion binding
metal ion binding
binding
catalytic activity
transition metal ion binding
Molecular Function
heme binding
guanylate cyclase activity
GTP binding
receptor activity
metal ion binding
Process
cyclic nucleotide biosynthetic process
metabolic process
cgmp biosynthetic process
nitrogen compound metabolic process
cellular nitrogen compound metabolic process
nucleobase, nucleoside, nucleotide and nucleic acid metabolic process
nucleoside monophosphate biosynthetic process
nucleoside monophosphate metabolic process
signaling pathway
signaling
intracellular signaling pathway
nucleobase, nucleoside and nucleotide metabolic process
nucleoside phosphate metabolic process
purine nucleotide biosynthetic process
purine nucleotide metabolic process
nucleotide metabolic process
Cellular Location
  1. Cytoplasm
Gene Properties
Chromosome Location 4
Locus 4q31.3-q33
SNPs GUCY1B3
Gene Sequence 
>1860 bp
ATGTACGGATTTGTGAATCACGCCCTGGAGTTGCTGGTGATCCGCAATTACGGCCCCGAG
GTGTGGGAAGACATCAAAAAAGAGGCACAGTTAGATGAAGAAGGACAGTTTCTTGTCAGA
ATAATATATGATGACTCCAAAACTTATGATTTGGTTGCTGCTGCAAGCAAAGTCCTCAAT
CTCAATGCTGGAGAAATCCTCCAAATGTTTGGGAAGATGTTTTTCGTCTTTTGCCAAGAA
TCTGGTTATGATACAATCTTGCGTGTCCTGGGCTCTAATGTCAGAGAATTTCTACAGAAC
CTTGATGCTCTGCACGACCACCTTGCTACCATCTACCCAGGAATGCGTGCACCTTCCTTT
AGGTGCACTGATGCAGAAAAGGGCAAAGGACTCATTTTGCACTACTACTCAGAGAGAGAA
GGACTTCAGGATATTGTCATTGGAATCATCAAAACAGTGGCACAACAAATCCATGGCACT
GAAATAGACATGAAGGTTATTCAGCAAAGAAATGAAGAATGTGATCATACTCAATTTTTA
ATTGAAGAAAAAGAGTCAAAAGAAGAGGATTTTTATGAAGATCTTGACAGATTTGAAGAA
AATGGTACCCAGGAATCACGCATCAGCCCATATACATTCTGCAAAGCTTTTCCTTTTCAT
ATAATATTTGACCGGGACCTAGTGGTCACTCAGTGTGGCAATGCTATATACAGAGTTCTC
CCCCAGCTCCAGCCTGGGAATTGCAGCCTTCTGTCTGTCTTCTCGCTGGTTCGTCCTCAT
ATTGATATTAGTTTCCATGGGATCCTTTCTCACATCAATACTGTTTTTGTATTGAGAAGC
AAGGAAGGATTGTTGGATGTGGAGAAATTAGAATGTGAGGATGAACTGACTGGGACTGAG
ATCAGCTGCTTACGTCTCAAGGGTCAAATGATCTACTTACCTGAAGCAGATAGCATACTT
TTTCTATGTTCACCAAGTGTCATGAACCTGGACGATTTGACAAGGAGAGGGCTGTATCTA
AGTGACATCCCTCTGCATGATGCCACGCGCGATCTTGTTCTTTTGGGAGAACAATTTAGA
GAGGAATACAAACTCACCCAAGAACTGGAAATCCTCACTGACAGGCTACAGCTCACGTTA
AGAGCCCTGGAAGATGAAAAGAAAAAGACAGACACATTGCTGTATTCTGTCCTTCCTCCG
TCTGTTGCCAATGAGCTGCGGCACAAGCGTCCAGTGCCTGCCAAAAGATATGACAATGTG
ACCATCCTCTTTAGTGGCATTGTGGGCTTCAATGCTTTCTGTAGCAAGCATGCATCTGGA
GAAGGAGCCATGAAGATCGTCAACCTCCTCAACGACCTCTACACCAGATTTGACACACTG
ACTGATTCCCGGAAAAACCCATTTGTTTATAAGGTGGAGACTGTTGGTGACAAGTATATG
ACAGTGAGTGGTTTACCAGAGCCATGCATTCACCATGCACGATCCATCTGCCACCTGGCC
TTGGACATGATGGAAATTGCTGGCCAGGTTCAAGTAGATGGTGAATCTGTTCAGATAACA
ATAGGGATACACACTGGAGAGGTAGTTACAGGTGTCATAGGACAGCGGATGCCTCGATAC
TGTCTTTTTGGGAATACTGTCAACCTCACAAGCCGAACAGAAACCACAGGAGAAAAGGGA
AAAATAAATGTGTCTGAATATACATACAGATGTCTTATGTCTCCAGAAAATTCAGATCCA
CAATTCCACTTGGAGCACAGAGGCCCAGTGTCCATGAAGGGCAAAAAAGAACCAATGCAA
GTTTGGTTTCTATCCAGAAAAAATACAGGAACAGAGGAAACAAAGCAGGATGATGACTGA
Protein Properties
Number of Residues 619
Molecular Weight 70513.89
Theoretical pI 5.355
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence 
>Guanylate cyclase soluble subunit beta-1
MYGFVNHALELLVIRNYGPEVWEDIKKEAQLDEEGQFLVRIIYDDSKTYDLVAAASKVLN
LNAGEILQMFGKMFFVFCQESGYDTILRVLGSNVREFLQNLDALHDHLATIYPGMRAPSF
RCTDAEKGKGLILHYYSEREGLQDIVIGIIKTVAQQIHGTEIDMKVIQQRNEECDHTQFL
IEEKESKEEDFYEDLDRFEENGTQESRISPYTFCKAFPFHIIFDRDLVVTQCGNAIYRVL
PQLQPGNCSLLSVFSLVRPHIDISFHGILSHINTVFVLRSKEGLLDVEKLECEDELTGTE
ISCLRLKGQMIYLPEADSILFLCSPSVMNLDDLTRRGLYLSDIPLHDATRDLVLLGEQFR
EEYKLTQELEILTDRLQLTLRALEDEKKKTDTLLYSVLPPSVANELRHKRPVPAKRYDNV
TILFSGIVGFNAFCSKHASGEGAMKIVNLLNDLYTRFDTLTDSRKNPFVYKVETVGDKYM
TVSGLPEPCIHHARSICHLALDMMEIAGQVQVDGESVQITIGIHTGEVVTGVIGQRMPRY
CLFGNTVNLTSRTETTGEKGKINVSEYTYRCLMSPENSDPQFHLEHRGPVSMKGKKEPMQ
VWFLSRKNTGTEETKQDDD
GenBank ID Protein 4504215
UniProtKB/Swiss-Prot ID Q02153
UniProtKB/Swiss-Prot Entry Name GCYB1_HUMAN
PDB IDs
GenBank Gene ID NM_000857.2
GeneCard ID GUCY1B3
GenAtlas ID GUCY1B3
HGNC ID HGNC:4687
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Giuili G, Scholl U, Bulle F, Guellaen G: Molecular cloning of the cDNAs coding for the two subunits of soluble guanylyl cyclase from human brain. FEBS Lett. 1992 Jun 8;304(1):83-8. [PubMed:1352257 ]
  3. Chhajlani V, Frandberg PA, Ahlner J, Axelsson KL, Wikberg JE: Heterogeneity in human soluble guanylate cyclase due to alternative splicing. FEBS Lett. 1991 Sep 23;290(1-2):157-8. [PubMed:1680753 ]