Hmdb loader
Identification
HMDB Protein ID HMDBP00699
Secondary Accession Numbers
  • 5972
  • HMDBP04888
Name 3-oxo-5-alpha-steroid 4-dehydrogenase 1
Synonyms
  1. S5AR 1
  2. SR type 1
  3. Steroid 5-alpha-reductase 1
Gene Name SRD5A1
Protein Type Enzyme
Biological Properties
General Function Involved in 3-oxo-5-alpha-steroid 4-dehydrogenase activity
Specific Function Converts testosterone into 5-alpha-dihydrotestosterone and progesterone or corticosterone into their corresponding 5-alpha-3-oxosteroids. It plays a central role in sexual differentiation and androgen physiology.
Pathways
  • 17-Beta Hydroxysteroid Dehydrogenase III Deficiency
  • Androgen and Estrogen Metabolism
  • Androstenedione Metabolism
  • Aromatase deficiency
  • Steroid hormone biosynthesis
Reactions
A 3-oxo-5-alpha-steroid + NADP → a 3-oxo-Delta(4)-steroid + NADPH details
Androstanedione + Acceptor → Androstenedione + Reduced acceptor details
Dihydrotestosterone + Acceptor → Testosterone + Reduced acceptor details
GO Classification
Biological Process
response to fungicide
cell differentiation
progesterone metabolic process
male gonad development
pituitary gland development
bone development
serotonin metabolic process
cellular response to dexamethasone stimulus
response to follicle-stimulating hormone stimulus
cellular response to cAMP
response to growth hormone stimulus
cellular response to growth factor stimulus
female genitalia development
hippocampus development
cellular response to starvation
hypothalamus development
male genitalia development
spinal cord development
thalamus development
cerebral cortex development
cellular response to epinephrine stimulus
cellular response to estradiol stimulus
circadian sleep/wake cycle, REM sleep
diterpenoid metabolic process
response to muscle activity
sex determination
urogenital system development
cellular response to insulin stimulus
response to drug
liver development
cellular response to testosterone stimulus
androgen biosynthetic process
small molecule metabolic process
Cellular Component
perinuclear region of cytoplasm
myelin sheath
integral to membrane
cell body fiber
endoplasmic reticulum membrane
neuronal cell body
Component
cell part
intracellular part
membrane
membrane part
intrinsic to membrane
cytoplasm
integral to membrane
Function
steroid dehydrogenase activity
steroid dehydrogenase activity, acting on the ch-ch group of donors
3-oxo-5-alpha-steroid 4-dehydrogenase activity
oxidoreductase activity, acting on the ch-ch group of donors
catalytic activity
oxidoreductase activity
Molecular Function
NADPH binding
electron carrier activity
3-oxo-5-alpha-steroid 4-dehydrogenase activity
cholestenone 5-alpha-reductase activity
amide binding
Process
metabolic process
primary metabolic process
oxidation reduction
lipid metabolic process
steroid metabolic process
Cellular Location
  1. Multi-pass membrane protein (Potential)
  2. Endoplasmic reticulum membrane
  3. Multi-pass membrane protein
  4. Microsome membrane
Gene Properties
Chromosome Location 5
Locus 5p15
SNPs SRD5A1
Gene Sequence
>780 bp
ATGGCAACGGCGACGGGGGTGGCGGAGGAGCGCCTGCTGGCCGCGCTCGCCTACCTGCAG
TGCGCCGTGGGCTGCGCGGTCTTCGCGCGGAATCGTCAGACGAACTCAGTGTACGGCCGC
CACGCGCTGCCCAGCCACAGGCTCCGAGTGCCGGCGCGGGCCGCCTGGGTGGTGCAGGAG
CTGCCCTCGCTGGCCCTGCCGCTCTACCAGTACGCCAGCGAGTCCGCCCCGCGTCTCCGC
AGCGCGCCCAACTGCATCCTCCTGGCCATGTTCCTCGTCCACTACGGGCATCGGTGCTTA
ATTTACCCGTTTCTGATGCGAGGAGGAAAGCCTATGCCACTGTTGGCATGTACAATGGCG
ATTATGTTCTGTACCTGTAACGGCTATTTGCAAAGCAGATACTTGAGCCATTGTGCAGTG
TATGCTGATGACTGGGTAACAGATCCCCGTTTTCTAATAGGTTTTGGCTTGTGGTTAACA
GGCATGTTGATAAACATCCATTCAGATCATATCCTAAGGAATCTCAGAAAACCAGGAGAT
ACTGGATACAAAATACCAAGGGGAGGCTTATTTGAATACGTAACTGCAGCCAACTATTTT
GGAGAAATCATGGAGTGGTGTGGCTATGCCCTGGCCAGCTGGTCTGTCCAAGGCGCGGCT
TTTGCTTTCTTCACGTTTTGTTTTTTATCTGGTAGAGCAAAAGAGCATCATGAGTGGTAC
CTCCGGAAATTTGAAGAGTATCCAAAGTTCAGAAAAATTATAATTCCATTTTTGTTTTAA
Protein Properties
Number of Residues 259
Molecular Weight 29458.18
Theoretical pI 8.942
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence
>3-oxo-5-alpha-steroid 4-dehydrogenase 1
MATATGVAEERLLAALAYLQCAVGCAVFARNRQTNSVYGRHALPSHRLRVPARAAWVVQE
LPSLALPLYQYASESAPRLRSAPNCILLAMFLVHYGHRCLIYPFLMRGGKPMPLLACTMA
IMFCTCNGYLQSRYLSHCAVYADDWVTDPRFLIGFGLWLTGMLINIHSDHILRNLRKPGD
TGYKIPRGGLFEYVTAANYFGEIMEWCGYALASWSVQGAAFAFFTFCFLSGRAKEHHEWY
LRKFEEYPKFRKIIIPFLF
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P18405
UniProtKB/Swiss-Prot Entry Name S5A1_HUMAN
PDB IDs Not Available
GenBank Gene ID M32313
GeneCard ID SRD5A1
GenAtlas ID SRD5A1
HGNC ID HGNC:11284
References
General References
  1. Ota T, Suzuki Y, Nishikawa T, Otsuki T, Sugiyama T, Irie R, Wakamatsu A, Hayashi K, Sato H, Nagai K, Kimura K, Makita H, Sekine M, Obayashi M, Nishi T, Shibahara T, Tanaka T, Ishii S, Yamamoto J, Saito K, Kawai Y, Isono Y, Nakamura Y, Nagahari K, Murakami K, Yasuda T, Iwayanagi T, Wagatsuma M, Shiratori A, Sudo H, Hosoiri T, Kaku Y, Kodaira H, Kondo H, Sugawara M, Takahashi M, Kanda K, Yokoi T, Furuya T, Kikkawa E, Omura Y, Abe K, Kamihara K, Katsuta N, Sato K, Tanikawa M, Yamazaki M, Ninomiya K, Ishibashi T, Yamashita H, Murakawa K, Fujimori K, Tanai H, Kimata M, Watanabe M, Hiraoka S, Chiba Y, Ishida S, Ono Y, Takiguchi S, Watanabe S, Yosida M, Hotuta T, Kusano J, Kanehori K, Takahashi-Fujii A, Hara H, Tanase TO, Nomura Y, Togiya S, Komai F, Hara R, Takeuchi K, Arita M, Imose N, Musashino K, Yuuki H, Oshima A, Sasaki N, Aotsuka S, Yoshikawa Y, Matsunawa H, Ichihara T, Shiohata N, Sano S, Moriya S, Momiyama H, Satoh N, Takami S, Terashima Y, Suzuki O, Nakagawa S, Senoh A, Mizoguchi H, Goto Y, Shimizu F, Wakebe H, Hishigaki H, Watanabe T, Sugiyama A, Takemoto M, Kawakami B, Yamazaki M, Watanabe K, Kumagai A, Itakura S, Fukuzumi Y, Fujimori Y, Komiyama M, Tashiro H, Tanigami A, Fujiwara T, Ono T, Yamada K, Fujii Y, Ozaki K, Hirao M, Ohmori Y, Kawabata A, Hikiji T, Kobatake N, Inagaki H, Ikema Y, Okamoto S, Okitani R, Kawakami T, Noguchi S, Itoh T, Shigeta K, Senba T, Matsumura K, Nakajima Y, Mizuno T, Morinaga M, Sasaki M, Togashi T, Oyama M, Hata H, Watanabe M, Komatsu T, Mizushima-Sugano J, Satoh T, Shirai Y, Takahashi Y, Nakagawa K, Okumura K, Nagase T, Nomura N, Kikuchi H, Masuho Y, Yamashita R, Nakai K, Yada T, Nakamura Y, Ohara O, Isogai T, Sugano S: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nat Genet. 2004 Jan;36(1):40-5. Epub 2003 Dec 21. [PubMed:14702039 ]
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  3. Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. Proc Natl Acad Sci U S A. 2000 Aug 15;97(17):9543-8. [PubMed:10931946 ]
  4. Andersson S, Russell DW: Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases. Proc Natl Acad Sci U S A. 1990 May;87(10):3640-4. [PubMed:2339109 ]
  5. Jenkins EP, Hsieh CL, Milatovich A, Normington K, Berman DM, Francke U, Russell DW: Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue. Genomics. 1991 Dec;11(4):1102-12. [PubMed:1686016 ]
  6. Eminovic I, Liovic M, Prezelj J, Kocijancic A, Rozman D, Komel R: New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8. Pflugers Arch. 2001;442(6 Suppl 1):R187-9. [PubMed:11678334 ]