Human Metabolome Database: Showing Protein Protein-glutamine gamma-glutamyltransferase 4 (HMDBP00681)

Identification Biological properties Gene properties Protein properties External links References XML Show 3 metabolites

Identification

HMDB Protein ID

HMDBP00681

Secondary Accession Numbers

5954

Name

Protein-glutamine gamma-glutamyltransferase 4

Synonyms

Fibrinoligase
Prostate transglutaminase
Prostate-specific transglutaminase
TG(P)
TGP
TGase P
TGase-4
Transglutaminase P
Transglutaminase-4

Gene Name

TGM4

Protein Type

Unknown

Biological Properties

General Function

Involved in protein-glutamine gamma-glutamyltransferase activity

Specific Function

Associated with the mammalian reproductive process. Catalyzes the cross-linking of proteins and the conjugation of polyamines to specific proteins in the seminal tract.

Pathways

Not Available

Reactions

Protein glutamine + alkylamine → protein N(5)-alkylglutamine + Ammonia

details

GO Classification

Biological Process
peptide cross-linking
protein polyamination
Function
catalytic activity
transferase activity
transferase activity, transferring acyl groups
transferase activity, transferring amino-acyl groups
protein-glutamine gamma-glutamyltransferase activity
Molecular Function
metal ion binding
protein-glutamine gamma-glutamyltransferase activity
Process
metabolic process
macromolecule metabolic process
macromolecule modification
protein modification process
post-translational protein modification
peptide cross-linking

Cellular Location

Not Available

Gene Properties

Chromosome Location

Locus

3p22-p21.33

SNPs

TGM4

Gene Sequence

>2055 bp
ATGATGGATGCATCAAAAGAGCTGCAAGTTCTCCACATTGACTTCTTGAATCAGGACAAC
GCCGTTTCTCACCACACATGGGAGTTCCAAACGAGCAGTCCTGTGTTCCGGCGAGGACAG
GTGTTTCACCTGCGGCTGGTGCTGAACCAGCCCCTACAATCCTACCACCAACTGAAACTG
GAATTCAGCACAGGGCCGAATCCTAGCATCGCCAAACACACCCTGGTGGTGCTCGACCCG
AGGACGCCCTCAGACCACTACAACTGGCAGGCAACCCTTCAAAATGAGTCTGGCAAAGAG
GTCACAGTGGCTGTCACCAGTTCCCCCAATGCCATCCTGGGCAAGTACCAACTAAACGTG
AAAACTGGAAACCACATCCTTAAGTCTGAAGAAAACATCCTATACCTTCTCTTCAACCCA
TGGTGTAAAGAGGACATGGTTTTCATGCCTGATGAGGACGAGCGCAAAGAGTACATCCTC
AATGACACGGGCTGCCATTACGTGGGGGCTGCCAGAAGTATCAAATGCAAACCCTGGAAC
TTTGGTCAGTTTGAGAAAAATGTCCTGGACTGCTGCATTTCCCTGCTGACTGAGAGCTCC
CTCAAGCCCACAGATAGGAGGGACCCCGTGCTGGTGTGCAGGGCCATGTGTGCTATGATG
AGCTTTGAGAAAGGCCAGGGCGTGCTCATTGGGAATTGGACTGGGGACTACGAAGGTGGC
ACAGCCCCATACAAGTGGACAGGCAGTGCCCCGATCCTGCAGCAGTACTACAACACGAAG
CAGGCTGTGTGCTTTGGCCAGTGCTGGGTGTTTGCTGGGATCCTGACTACAGTGCTGAGA
GCGTTGGGCATCCCAGCACGCAGTGTGACAGGCTTCGATTCAGCTCACGACACAGAAAGG
AACCTCACGGTGGACACCTATGTGAATGAGAATGGCGAGAAAATCACCAGTATGACCCAC
GACTCTGTCTGGAATTTCCATGTGTGGACGGATGCCTGGATGAAGCGACCGGATCTGCCC
AAGGGCTACGACGGCTGGCAGGCTGTGGACGCAACGCCGCAGGAGCGAAGCCAGGGTGTC
TTCTGCTGTGGGCCATCACCACTGACCGCCATCCGCAAAGGTGACATCTTTATTGTCTAT
GACACCAGATTCGTCTTCTCAGAAGTGAATGGTGACAGGCTCATCTGGTTGGTGAAGATG
GTGAATGGGCAGGAGGAGTTACACGTAATTTCAATGGAGACCACAAGCATCGGGAAAAAC
ATCAGCACCAAGGCAGTGGGCCAAGACAGGCGGAGAGATATCACCTATGAGTACAAGTAT
CCAGAAGGCTCCTCTGAGGAGAGGCAGGTCATGGATCATGCCTTCCTCCTTCTCAGTTCT
GAGAGGGAGCACAGACGACCTGTAAAAGAGAACTTTCTTCACATGTCGGTACAATCAGAT
GATGTGCTGCTGGGAAACTCTGTTAATTTCACCGTGATTCTTAAAAGGAAGACCGCTGCC
CTACAGAATGTCAACATCTTGGGCTCCTTTGAACTACAGTTGTACACTGGCAAGAAGATG
GCAAAACTGTGTGACCTCAATAAGACCTCGCAGATCCAAGGTCAAGTATCAGAAGTGACT
CTGACCTTGGACTCCAAGACCTACATCAACAGCCTGGCTATATTAGATGATGAGCCAGTT
ATCAGAGGTTTCATCATTGCGGAAATTGTGGAGTCTAAGGAAATCATGGCCTCTGAAGTA
TTCACGTCTTTCCAGTACCCTGAGTTCTCTATAGAGTTGCCTAACACAGGCAGAATTGGC
CAGCTACTTGTCTGCAATTGTATCTTCAAGAATACCCTGGCCATCCCTTTGACTGACGTC
AAGTTCTCTTTGGAAAGCCTGGGCATCTCCTCACTACAGACCTCTGACCATGGGACGGTG
CAGCCTGGTGAGACCATCCAATCCCAAATAAAATGCACCCCAATAAAAACTGGACCCAAG
AAATTTATCGTCAAGTTAAGTTCCAAACAAGTGAAAGAGATTAATGCTCAGAAGATTGTT
CTCATCACCAAGTAG

Protein Properties

Number of Residues

684

Molecular Weight

77144.595

Theoretical pI

6.76

Pfam Domain Function

Transglut_C (PF00927 )
Transglut_core (PF01841 )
Transglut_N (PF00868 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Protein-glutamine gamma-glutamyltransferase 4
MMDASKELQVLHIDFLNQDNAVSHHTWEFQTSSPVFRRGQVFHLRLVLNQPLQSYHQLKL
EFSTGPNPSIAKHTLVVLDPRTPSDHYNWQATLQNESGKEVTVAVTSSPNAILGKYQLNV
KTGNHILKSEENILYLLFNPWCKEDMVFMPDEDERKEYILNDTGCHYVGAARSIKCKPWN
FGQFEKNVLDCCISLLTESSLKPTDRRDPVLVCRAMCAMMSFEKGQGVLIGNWTGDYEGG
TAPYKWTGSAPILQQYYNTKQAVCFGQCWVFAGILTTVLRALGIPARSVTGFDSAHDTER
NLTVDTYVNENGEKITSMTHDSVWNFHVWTDAWMKRPDLPKGYDGWQAVDATPQERSQGV
FCCGPSPLTAIRKGDIFIVYDTRFVFSEVNGDRLIWLVKMVNGQEELHVISMETTSIGKN
ISTKAVGQDRRRDITYEYKYPEGSSEERQVMDHAFLLLSSEREHRRPVKENFLHMSVQSD
DVLLGNSVNFTVILKRKTAALQNVNILGSFELQLYTGKKMAKLCDLNKTSQIQGQVSEVT
LTLDSKTYINSLAILDDEPVIRGFIIAEIVESKEIMASEVFTSFQYPEFSIELPNTGRIG
QLLVCNCIFKNTLAIPLTDVKFSLESLGISSLQTSDHGTVQPGETIQSQIKCTPIKTGPK
KFIVKLSSKQVKEINAQKIVLITK

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P49221

UniProtKB/Swiss-Prot Entry Name

TGM4_HUMAN

PDB IDs

Not Available

GenBank Gene ID

GeneCard ID

GenAtlas ID

HGNC ID

References

General References

Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
Grant FJ, Taylor DA, Sheppard PO, Mathewes SL, Lint W, Vanaja E, Bishop PD, O'Hara PJ: Molecular cloning and characterization of a novel transglutaminase cDNA from a human prostate cDNA library. Biochem Biophys Res Commun. 1994 Sep 15;203(2):1117-23. [PubMed:7916568 ]
Dubbink HJ, Verkaik NS, Faber PW, Trapman J, Schroder FH, Romijn JC: Tissue specific and androgen-regulated expression of human prostate-specific transglutaminase. Biochem J. 1996 May 1;315 ( Pt 3):901-8. [PubMed:8645175 ]