| HMDB0000027 | Tetrahydrobiopterin | 62989-33-7 |  | C9H15N5O3 | 241.2471
241.117489371 | - Andersen OA, Flatmark T, Hough E: High resolution crystal structures of the catalytic domain of human phenylalanine hydroxylase in its catalytically active Fe(II) form and binary complex with tetrahydrobiopterin. J Mol Biol. 2001 Nov 23;314(2):279-91. [PubMed:11718561 ]
|
| HMDB0000068 | Epinephrine | 51-43-4 |  | C9H13NO3 | 183.2044
183.089543287 | Not Available |
| HMDB0000158 | L-Tyrosine | 60-18-4 |  | C9H11NO3 | 181.1885
181.073893223 | Not Available |
| HMDB0000159 | Phenylalanine | 63-91-2 |  | C9H11NO2 | 165.1891
165.078978601 | - Fusetti F, Erlandsen H, Flatmark T, Stevens RC: Structure of tetrameric human phenylalanine hydroxylase and its implications for phenylketonuria. J Biol Chem. 1998 Jul 3;273(27):16962-7. [PubMed:9642259 ]
- Thorolfsson M, Ibarra-Molero B, Fojan P, Petersen SB, Sanchez-Ruiz JM, Martinez A: L-phenylalanine binding and domain organization in human phenylalanine hydroxylase: a differential scanning calorimetry study. Biochemistry. 2002 Jun 18;41(24):7573-85. [PubMed:12056888 ]
- Pueschel SM, Boylan J, Ellenbogen R: Studies on experimentally induced hyperphenylalaninemia. J Ment Defic Res. 1988 Aug;32 ( Pt 4):309-19. [PubMed:2975336 ]
- Nagasaki Y, Matsubara Y, Takano H, Fujii K, Senoo M, Akanuma J, Takahashi K, Kure S, Hara M, Kanegae Y, Saito I, Narisawa K: Reversal of hypopigmentation in phenylketonuria mice by adenovirus-mediated gene transfer. Pediatr Res. 1999 Apr;45(4 Pt 1):465-73. [PubMed:10203136 ]
- Stokka AJ, Flatmark T: Substrate-induced conformational transition in human phenylalanine hydroxylase as studied by surface plasmon resonance analyses: the effect of terminal deletions, substrate analogues and phosphorylation. Biochem J. 2003 Feb 1;369(Pt 3):509-18. [PubMed:12379147 ]
|
| HMDB0000216 | Norepinephrine | 51-41-2 |  | C8H11NO3 | 169.1778
169.073893223 | - Overington JP, Al-Lazikani B, Hopkins AL: How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6. [PubMed:17139284 ]
- Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Nat Rev Drug Discov. 2006 Oct;5(10):821-34. [PubMed:17016423 ]
- Martinez A, Andersson KK, Haavik J, Flatmark T: EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors. Eur J Biochem. 1991 Jun 15;198(3):675-82. [PubMed:1646718 ]
- Martinez A, Haavik J, Flatmark T: Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase. Eur J Biochem. 1990 Oct 5;193(1):211-9. [PubMed:2226440 ]
- Molinoff PB: The regulation of the noradrenergic neuron. J Psychiatr Res. 1974;11:339-45. [PubMed:4156788 ]
|
| HMDB0000692 | Fe2+ | 15438-31-0 |  | Fe | 55.845
55.934942133 | Not Available |
| HMDB0001377 | Oxygen | 7782-44-7 |  | O2 | 31.9988
31.989829244 | Not Available |
| HMDB0002111 | Water | 7732-18-5 |  | H2O | 18.0153
18.010564686 | Not Available |
| HMDB0002215 | 4a-Carbinolamine tetrahydrobiopterin | 79647-29-3 |  | C9H13N5O3 | 239.2312
239.101839307 | Not Available |
| HMDB0002281 | 4a-Hydroxytetrahydrobiopterin | 1379003-93-6 |  | C9H15N5O4 | 257.25
257.112403983 | Not Available |
| HMDB0015627 | Droxidopa | 23651-95-8 |  | C9H11NO5 | 213.1873
213.063722467 | - Martinez A, Andersson KK, Haavik J, Flatmark T: EPR and 1H-NMR spectroscopic studies on the paramagnetic iron at the active site of phenylalanine hydroxylase and its interaction with substrates and inhibitors. Eur J Biochem. 1991 Jun 15;198(3):675-82. [PubMed:1646718 ]
- Martinez A, Haavik J, Flatmark T: Cooperative homotropic interaction of L-noradrenaline with the catalytic site of phenylalanine 4-monooxygenase. Eur J Biochem. 1990 Oct 5;193(1):211-9. [PubMed:2226440 ]
- Molinoff PB: The regulation of the noradrenergic neuron. J Psychiatr Res. 1974;11:339-45. [PubMed:4156788 ]
|
