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Showing metabocard for 11-Dehydrocorticosterone (HMDB0004029)

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IdentificationTaxonomyOntologyPhysical propertiesSpectraBiological propertiesConcentrationsLinksReferencesenzymes (3) Show 3 proteinsXML
enzymes (3) Show 3 proteins
Record Information
Version5.0
StatusDetected and Quantified
Creation Date2006-08-13 09:21:39 UTC
Update Date2022-03-07 02:49:20 UTC
HMDB IDHMDB0004029
Secondary Accession Numbers
  • HMDB04029
Metabolite Identification
Common Name11-Dehydrocorticosterone
Description11-Dehydrocorticosterone is a mineral corticosteroid. The conversion of inactive 11-ketoglucocorticoids such as 11-dehydrocorticosterone) into active 11b-hydroxyglucocorticoids (such as corticosterone) is catalyzed by 11beta-hydroxysteroid dehydrogenase (11b-HSD1, EC 1.1.1.146), which is expressed in many tissues and plays an important role in metabolically relevant tissues such as the liver, adipose tissue, skeletal muscles and possibly kidney. Chronically elevated local glucocorticoid action as a result of increased 11beta-HSD1 activity rather than elevated systemic glucocorticoid levels has been associated with metabolic syndrome, which is characterized by obesity, insulin resistance, type 2 diabetes and cardiovascular complications. Recent studies indicate that compounds inhibiting 11beta-HSD1 activity ameliorate the adverse effects of excessive glucocorticoid concentrations on metabolic processes, providing promising opportunities for the development of therapeutic interventions. 11-dehydrocorticosterone and corticosterone display antinatriuretic activity, although 11-dehydrocorticosterone is generally a more potent sodium retainer than corticosterone. (PMID: 17584152 , Endocr Metab Immune Disord Drug Targets. 2007 Jun;7(2):125-40.).
Structure
Data?1582752294
MOLSDFPDBSMILESInChI

MOL for HMDB0004029 (11-Dehydrocorticosterone)

Not Available

3D MOL for HMDB0004029 (11-Dehydrocorticosterone)

Not Available

3D SDF for HMDB0004029 (11-Dehydrocorticosterone)

Not Available

3D-SDF for HMDB0004029 (11-Dehydrocorticosterone)

Not Available

PDB for HMDB0004029 (11-Dehydrocorticosterone)

Not Available

3D PDB for HMDB0004029 (11-Dehydrocorticosterone)

Not Available

SMILES for HMDB0004029 (11-Dehydrocorticosterone)

Not Available

INCHI for HMDB0004029 (11-Dehydrocorticosterone)

Not Available
View in JSmolView Stereo Labels
SynonymsNot Available
Chemical FormulaC21H28O4
Average Molecular Weight344.4446
Monoisotopic Molecular Weight344.198759384
IUPAC NameNot Available
Traditional NameNot Available
CAS Registry Number72-23-1
SMILESNot Available
InChI Identifier
InChI=1S/C21H28O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-16,19,22H,3-8,10-11H2,1-2H3/t14-,15-,16?,19+,20-,21-/m0/s1
InChI KeyFUFLCEKSBBHCMO-IWBQTIMDSA-N
Chemical Taxonomy
ClassificationNot classified
Ontology
Physiological effect
Health effect
Disposition
Biological locationRoute of exposureSource
Process
Naturally occurring process
Role
Biological roleIndustrial application
Physical Properties
StateSolid
Experimental Molecular Properties
PropertyValueReference
Melting Point183.5 °CNot Available
Boiling PointNot AvailableNot Available
Water SolubilityNot AvailableNot Available
LogPNot AvailableNot Available
Experimental Chromatographic Properties
Predicted Molecular PropertiesNot Available
Predicted Chromatographic Properties

Predicted Retention Times

Underivatized

Chromatographic MethodRetention TimeReference
Measured using a Waters Acquity ultraperformance liquid chromatography (UPLC) ethylene-bridged hybrid (BEH) C18 column (100 mm × 2.1 mm; 1.7 μmparticle diameter). Predicted by Afia on May 17, 2022. Predicted by Afia on May 17, 2022.5.74 minutes32390414
Predicted by Siyang on May 30, 202212.8227 minutes33406817
Predicted by Siyang using ReTip algorithm on June 8, 20221.21 minutes32390414
Fem_Long = Waters ACQUITY UPLC HSS T3 C18 with Water:MeOH and 0.1% Formic Acid2511.9 seconds40023050
Fem_Lipids = Ascentis Express C18 with (60:40 water:ACN):(90:10 IPA:ACN) and 10mM NH4COOH + 0.1% Formic Acid230.5 seconds40023050
Life_Old = Waters ACQUITY UPLC BEH C18 with Water:(20:80 acetone:ACN) and 0.1% Formic Acid185.2 seconds40023050
Life_New = RP Waters ACQUITY UPLC HSS T3 C18 with Water:(30:70 MeOH:ACN) and 0.1% Formic Acid172.1 seconds40023050
RIKEN = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid231.7 seconds40023050
Eawag_XBridgeC18 = XBridge C18 3.5u 2.1x50 mm with Water:MeOH and 0.1% Formic Acid489.6 seconds40023050
BfG_NTS_RP1 =Agilent Zorbax Eclipse Plus C18 (2.1 mm x 150 mm, 3.5 um) with Water:ACN and 0.1% Formic Acid546.0 seconds40023050
HILIC_BDD_2 = Merck SeQuant ZIC-HILIC with ACN(0.1% formic acid):water(16 mM ammonium formate)120.5 seconds40023050
UniToyama_Atlantis = RP Waters Atlantis T3 (2.1 x 150 mm, 5 um) with ACN:Water and 0.1% Formic Acid1066.2 seconds40023050
BDD_C18 = Hypersil Gold 1.9µm C18 with Water:ACN and 0.1% Formic Acid431.0 seconds40023050
UFZ_Phenomenex = Kinetex Core-Shell C18 2.6 um, 3.0 x 100 mm, Phenomenex with Water:MeOH and 0.1% Formic Acid1393.4 seconds40023050
SNU_RIKEN_POS = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid287.7 seconds40023050
RPMMFDA = Waters ACQUITY UPLC BEH C18 with Water:ACN and 0.1% Formic Acid407.0 seconds40023050
MTBLS87 = Merck SeQuant ZIC-pHILIC column with ACN:Water and :ammonium carbonate304.0 seconds40023050
KI_GIAR_zic_HILIC_pH2_7 = Merck SeQuant ZIC-HILIC with ACN:Water and 0.1% FA267.7 seconds40023050
Meister zic-pHILIC pH9.3 = Merck SeQuant ZIC-pHILIC column with ACN:Water 5mM NH4Ac pH9.3 and 5mM ammonium acetate in water41.8 seconds40023050

Predicted Kovats Retention Indices

Underivatized

MetaboliteSMILESKovats RI ValueColumn TypeReference
11-Dehydrocorticosterone[H][C@@]12CCC(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C3550.9Standard polar33892256
11-Dehydrocorticosterone[H][C@@]12CCC(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C2906.6Standard non polar33892256
11-Dehydrocorticosterone[H][C@@]12CCC(C(=O)CO)[C@@]1(C)CC(=O)[C@@]1([H])[C@@]2([H])CCC2=CC(=O)CC[C@]12C3270.5Semi standard non polar33892256

Derivatized

Derivative Name / StructureSMILESKovats RI ValueColumn TypeReference
11-Dehydrocorticosterone,1TMS,isomer #1C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3316.3Semi standard non polar33892256
11-Dehydrocorticosterone,1TMS,isomer #2C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3259.9Semi standard non polar33892256
11-Dehydrocorticosterone,1TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO)CC[C@@H]123146.5Semi standard non polar33892256
11-Dehydrocorticosterone,1TMS,isomer #4C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3288.7Semi standard non polar33892256
11-Dehydrocorticosterone,1TMS,isomer #5C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO)CC[C@@H]123185.0Semi standard non polar33892256
11-Dehydrocorticosterone,1TMS,isomer #6C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=O)CO3235.4Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123148.0Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123070.0Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123544.9Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #10C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C)CC[C@@H]123071.3Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #10C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C)CC[C@@H]122993.1Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #10C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C)CC[C@@H]123571.9Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #11C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3102.8Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #11C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C2925.8Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #11C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3612.1Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #12C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3185.9Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #12C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C2993.6Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #12C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3555.2Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #13C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO)CC[C@@H]123034.5Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #13C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO)CC[C@@H]123012.0Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #13C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO)CC[C@@H]123643.9Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #2C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3271.1Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #2C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3079.1Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #2C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3541.7Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123168.6Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]122996.2Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123605.4Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #4C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3209.4Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #4C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3071.4Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #4C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=O)CO[Si](C)(C)C3527.3Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #5C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3343.1Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #5C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3026.7Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #5C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3503.2Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #6C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123109.5Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #6C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123029.7Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #6C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123577.2Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #7C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3117.5Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #7C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C2967.4Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #7C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3627.2Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #8C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3189.6Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #8C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3032.9Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #8C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3563.9Standard polar33892256
11-Dehydrocorticosterone,2TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO)CC[C@@H]123039.6Semi standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO)CC[C@@H]123055.2Standard non polar33892256
11-Dehydrocorticosterone,2TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO)CC[C@@H]123585.7Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123091.7Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123125.5Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #1C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123528.9Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #10C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C2995.9Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #10C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3029.9Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #10C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO)O[Si](C)(C)C3610.3Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #11C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C)CC[C@@H]122979.3Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #11C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C)CC[C@@H]123095.9Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #11C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C)CC[C@@H]123566.1Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #12C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C2990.0Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #12C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C2986.7Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #12C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO)O[Si](C)(C)C3604.9Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123029.1Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123155.9Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123512.2Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123104.5Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123062.8Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #3C[C@]12CCC(=O)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123510.2Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #4C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3086.5Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #4C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3050.0Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #4C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3564.4Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #5C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3178.3Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #5C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3130.2Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #5C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3506.1Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123032.0Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123118.9Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #6C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1[C@@H]2C(O[Si](C)(C)C)=C[C@]2(C)C(C(=O)CO[Si](C)(C)C)CC[C@@H]123560.9Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #7C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3125.8Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #7C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C2983.6Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #7C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3543.5Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #8C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3195.5Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #8C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3070.4Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #8C[C@]12CC(=O)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3496.7Standard polar33892256
11-Dehydrocorticosterone,3TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123021.1Semi standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123146.6Standard non polar33892256
11-Dehydrocorticosterone,3TMS,isomer #9C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C)CC[C@@H]123564.3Standard polar33892256
11-Dehydrocorticosterone,4TMS,isomer #1C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]122997.8Semi standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #1C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123236.4Standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #1C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(=C(CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123464.7Standard polar33892256
11-Dehydrocorticosterone,4TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123000.6Semi standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123156.9Standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #2C[C@]12CC=C(O[Si](C)(C)C)C=C1CC[C@@H]1C2=C(O[Si](C)(C)C)C[C@]2(C)C(C(=CO[Si](C)(C)C)O[Si](C)(C)C)CC[C@@H]123481.8Standard polar33892256
11-Dehydrocorticosterone,4TMS,isomer #3C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C2973.8Semi standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #3C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3106.4Standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #3C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2=C(CO[Si](C)(C)C)O[Si](C)(C)C3518.0Standard polar33892256
11-Dehydrocorticosterone,4TMS,isomer #4C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3014.9Semi standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #4C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3045.3Standard non polar33892256
11-Dehydrocorticosterone,4TMS,isomer #4C[C@]12C=C(O[Si](C)(C)C)[C@H]3[C@@H](CCC4=CC(O[Si](C)(C)C)=CC[C@@]43C)[C@@H]1CCC2C(=CO[Si](C)(C)C)O[Si](C)(C)C3526.3Standard polar33892256
11-Dehydrocorticosterone,1TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3592.8Semi standard non polar33892256
11-Dehydrocorticosterone,1TBDMS,isomer #2CC(C)(C)[Si](C)(C)OC(CO)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3528.9Semi standard non polar33892256
11-Dehydrocorticosterone,1TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC1=C2[C@@H](CCC3=CC(=O)CC[C@@]32C)[C@@H]2CCC(C(=O)CO)[C@@]2(C)C13386.7Semi standard non polar33892256
11-Dehydrocorticosterone,1TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3514.9Semi standard non polar33892256
11-Dehydrocorticosterone,1TBDMS,isomer #5CC(C)(C)[Si](C)(C)OC1=C[C@]2(C)C(C(=O)CO)CC[C@H]2[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@@H]123422.3Semi standard non polar33892256
11-Dehydrocorticosterone,1TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(C(=O)CO)[C@@]3(C)CC(=O)[C@@H]123490.8Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3796.4Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3576.2Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3747.0Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3524.1Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3486.3Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3778.1Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(C(=CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC(=O)[C@@H]123663.5Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(C(=CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC(=O)[C@@H]123444.0Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(C(=CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC(=O)[C@@H]123774.4Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3564.6Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3343.4Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC(=CO)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3808.3Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #13CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2C(O[Si](C)(C)C(C)(C)C)=C[C@]2(C)C(C(=O)CO)CC[C@@H]123486.2Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #13CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2C(O[Si](C)(C)C(C)(C)C)=C[C@]2(C)C(C(=O)CO)CC[C@@H]123345.9Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #13CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1[C@@H]2C(O[Si](C)(C)C(C)(C)C)=C[C@]2(C)C(C(=O)CO)CC[C@@H]123844.3Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3622.1Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3565.4Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3755.2Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3806.6Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3507.0Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(=O)C[C@]12C3726.4Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3720.7Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3524.0Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #4CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3734.1Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3660.1Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3426.1Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3780.3Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=C2[C@@H](CCC3=CC(=O)CC[C@@]32C)[C@@H]2CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]2(C)C13598.6Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=C2[C@@H](CCC3=CC(=O)CC[C@@]32C)[C@@H]2CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]2(C)C13529.4Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC1=C2[C@@H](CCC3=CC(=O)CC[C@@]32C)[C@@H]2CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]2(C)C13782.0Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC(=O)[C@@H]123691.3Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC(=O)[C@@H]123467.8Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)CC(=O)[C@@H]123777.7Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC1=C[C@]2(C)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@@H]123586.3Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC1=C[C@]2(C)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@@H]123369.5Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #8CC(C)(C)[Si](C)(C)OC1=C[C@]2(C)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@H]2[C@@H]2CCC3=CC(=O)CC[C@]3(C)[C@@H]123818.3Standard polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(C(=O)CO)CC[C@@H]123504.9Semi standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(C(=O)CO)CC[C@@H]123484.1Standard non polar33892256
11-Dehydrocorticosterone,2TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(C(=O)CO)CC[C@@H]123799.8Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3796.4Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3812.2Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3796.1Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)C=C(O[Si](C)(C)C(C)(C)C)[C@@H]123655.0Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)C=C(O[Si](C)(C)C(C)(C)C)[C@@H]123546.6Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #10CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(=C(CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)C=C(O[Si](C)(C)C(C)(C)C)[C@@H]123860.0Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123636.2Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123670.0Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #11CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(C(=CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123836.6Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(C(=CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)C=C(O[Si](C)(C)C(C)(C)C)[C@@H]123658.1Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(C(=CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)C=C(O[Si](C)(C)C(C)(C)C)[C@@H]123530.9Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #12CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@H]1[C@@H]3CCC(C(=CO)O[Si](C)(C)C(C)(C)C)[C@@]3(C)C=C(O[Si](C)(C)C(C)(C)C)[C@@H]123861.5Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3881.8Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3743.6Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3758.8Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3753.0Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3617.6Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #3CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3803.8Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3743.9Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3727.3Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3777.2Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3670.8Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3755.0Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #5CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3776.2Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3879.8Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3665.6Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #6CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(=O)C[C@]12C3750.5Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3785.0Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3563.3Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #7CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3786.9Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3661.7Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3586.9Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #8CC(C)(C)[Si](C)(C)OCC(=O)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3783.4Standard polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123692.1Semi standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123712.5Standard non polar33892256
11-Dehydrocorticosterone,3TBDMS,isomer #9CC(C)(C)[Si](C)(C)OC1=CC[C@@]2(C)C(=C1)CC[C@@H]1C2=C(O[Si](C)(C)C(C)(C)C)C[C@]2(C)C(=C(CO)O[Si](C)(C)C(C)(C)C)CC[C@@H]123832.1Standard polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3849.2Semi standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3938.6Standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #1CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3740.8Standard polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3835.0Semi standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3753.4Standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #2CC(C)(C)[Si](C)(C)OCC(O[Si](C)(C)C(C)(C)C)=C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3755.4Standard polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3819.2Semi standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3856.7Standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #3CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)C3=C(O[Si](C)(C)C(C)(C)C)C[C@]12C3750.2Standard polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3847.9Semi standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3717.0Standard non polar33892256
11-Dehydrocorticosterone,4TBDMS,isomer #4CC(C)(C)[Si](C)(C)OC=C(O[Si](C)(C)C(C)(C)C)C1CC[C@H]2[C@@H]3CCC4=CC(O[Si](C)(C)C(C)(C)C)=CC[C@]4(C)[C@H]3C(O[Si](C)(C)C(C)(C)C)=C[C@]12C3765.9Standard polar33892256
Spectra
Biological Properties
Cellular Locations
  • Extracellular
  • Membrane
Biospecimen Locations
  • Blood
Tissue Locations
  • Adipose Tissue
  • Kidney
  • Liver
  • Placenta
Pathways
Normal Concentrations
Not Available
Abnormal Concentrations
BiospecimenStatusValueAgeSexConditionReferenceDetails
BloodDetected and Quantified0.0278 +/- 0.0060 uMElderly (>65 years old)Male
Kidney cancer		 details
BloodDetected and Quantified0.0142 +/- 0.0039 uMElderly (>65 years old)Male
Kidney Cancer		 details
BloodDetected and Quantified0.0204 +/- 0.0034 uMElderly (>65 years old)Female
Kidney Cancer		 details
BloodDetected and Quantified0.0336 +/- 0.0054 uMElderly (>65 years old)Female
Kidney Cancer		 details
Associated Disorders and Diseases
Disease References
Kidney cancer
  1. Tortorella C, Aragona F, Nussdorfer GG: In vivo evidence that human adrenal glands possess 11 beta-hydroxysteroid dehydrogenase activity. Life Sci. 1999;65(26):2823-7. [PubMed:10622271 ]
Associated OMIM IDsNone
External LinksNot Available
References
Synthesis ReferenceNikiforova, O. K.; Suvorov, N. N. Steroids. IV. Synthesis of 11-dehydrocorticosterone from 11-oxopregesterone. Zhurnal Obshchei Khimii (1959), 29 2428-31.
Material Safety Data Sheet (MSDS)Not Available
General References
  1. Ronquist-Nii Y, Edlund PO: Determination of corticosteroids in tissue samples by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal. 2005 Feb 23;37(2):341-50. [PubMed:15708676 ]
  2. Walker BR, Rodin A, Taylor NF, Clayton RN: Endogenous inhibitors of 11beta-hydroxysteroid dehydrogenase type 1 do not explain abnormal cortisol metabolism in polycystic ovary syndrome. Clin Endocrinol (Oxf). 2000 Jan;52(1):77-80. [PubMed:10651756 ]
  3. Edwards CR, Benediktsson R, Lindsay RS, Seckl JR: 11 beta-Hydroxysteroid dehydrogenases: key enzymes in determining tissue-specific glucocorticoid effects. Steroids. 1996 Apr;61(4):263-9. [PubMed:8733012 ]
  4. Livingstone DE, Jones GC, Smith K, Jamieson PM, Andrew R, Kenyon CJ, Walker BR: Understanding the role of glucocorticoids in obesity: tissue-specific alterations of corticosterone metabolism in obese Zucker rats. Endocrinology. 2000 Feb;141(2):560-3. [PubMed:10650936 ]
  5. Atanasov AG, Odermatt A: Readjusting the glucocorticoid balance: an opportunity for modulators of 11beta-hydroxysteroid dehydrogenase type 1 activity? Endocr Metab Immune Disord Drug Targets. 2007 Jun;7(2):125-40. [PubMed:17584152 ]

Enzymes

Enzyme Details
1. 3-oxo-5-beta-steroid 4-dehydrogenase
General function:
Involved in oxidoreductase activity
Specific function:
Efficiently catalyzes the reduction of progesterone, androstenedione, 17-alpha-hydroxyprogesterone and testosterone to 5-beta-reduced metabolites. The bile acid intermediates 7-alpha,12-alpha-dihydroxy-4-cholesten-3-one and 7-alpha-hydroxy-4-cholesten-3-one can also act as substrates.
Gene Name:
AKR1D1
Uniprot ID:
P51857
Molecular weight:
32889.38
Enzyme Details
2. Corticosteroid 11-beta-dehydrogenase isozyme 2
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes the conversion of cortisol to the inactive metabolite cortisone. Modulates intracellular glucocorticoid levels, thus protecting the nonselective mineralocorticoid receptor from occupation by glucocorticoids.
Gene Name:
HSD11B2
Uniprot ID:
P80365
Molecular weight:
44126.06
Enzyme Details
3. Corticosteroid 11-beta-dehydrogenase isozyme 1
General function:
Involved in oxidoreductase activity
Specific function:
Catalyzes reversibly the conversion of cortisol to the inactive metabolite cortisone. Catalyzes reversibly the conversion of 7-ketocholesterol to 7-beta-hydroxycholesterol. In intact cells, the reaction runs only in one direction, from 7-ketocholesterol to 7-beta-hydroxycholesterol (By similarity).
Gene Name:
HSD11B1
Uniprot ID:
P28845
Molecular weight:
32400.665
Reactions
Corticosterone + NADP → 11-Dehydrocorticosterone + NADPH + Hydrogen Iondetails